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BGC0001376PKS

WS79089A;Hexaricin B;Hexaricin C

Producing organism
Streptosporangium sp. FXJ7.131
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Streptosporangiaceae›Streptosporangium
Biosynthetic class
PKS (Unknown)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗
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C27H20O9488.11 Da

Gene Cluster Map33 genes · 35,845 bp

KSKS5 kb35.8 kb visible · 35,845 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
CycPolyketide cyclase

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1
AMK51279.1, AMK51280.1,…
+Malonyl-CoA, Malonyl-CoA
Step 2
AMK51287.1
Step 3
AMK51278.1, AMK51282.1,…
Step 4
AMK51276.1
Step 5
AMK51277.1, AMK51290.1
Step 6
AMK51264.1/AMK51266.1
Step 7
AMK51286.1?
Step 9
AMK51286.1?
Step 8
?
+1376(1), Acetyl-CoA
Step 10
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11376-1AMK51279.1, AMK51280.1, AMK51281.1—
Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
O=C(CC(CC(CC(CC(CC(O)=O)=O)=O)=O)=O)CC(CC(CC(CC(CC(CC(CC(C)=O)=O)=O)=O)=O)=O)=O—
21376-2AMK51287.1—
1376-1
from: 1376-1
OC(CC(CC(CC(CC(CC(O)=O)=O)=O)=O)=O)CC(CC(CC(CC(CC(CC(CC(C)=O)=O)=O)=O)=O)=O)=O—
31376-3AMK51278.1, AMK51282.1, AMK51283.1—
1376-2
from: 1376-2
OC1=C(C(O)=C(C(O)=C(C(CC2=C3C(O)=C(C(O)=O)C(CC(C)=O)=C2)=O)C3=C4)C4=C5)C5=CC=C1—
41376-4AMK51276.1—
1376-3
from: 1376-3
OC1=C(C(O)=C(C(O)=C([C@H](O)CC2=C3C(O)=C(C(O)=O)C(CC(C)=O)=C2)C3=C4)C4=C5)C5=CC=C1—
51376-5AMK51277.1, AMK51290.1—
1376-4
from: 1376-4
OC1=C(C(C2=C3C(O)=C4C([C@H](O)CC5=C4C(O)=C(C(O)=O)C(CC(C)=O)=C5)=C2O)=O)C(C3=O)=CC=C1—
61376-6AMK51264.1/AMK51266.1—
1376-5
from: 1376-5
OC1=C(C(C2=C3C(O)=C4C([C@H](O)CC5=C4C(O)=C(C(O)=O)C(CC(C)=O)=C5)=C2OC)=O)C(C3=O)=CC=C1—
71376(1)AMK51286.1?—
1376-6
from: 1376-6
OC1=C(C(C2=C3C(O)=C4C([C@H](O)CC5=C4C(O)=C(C(O[C@H](C)C6)=O)C6=C5)=C2OC)=O)C(C3=O)=CC=C1—
81376(2)?—
1376(1);Acetyl-CoA
OC1=C(C(C2=C3C(O)=C4C([C@H](OC(C)=O)CC5=C4C(O)=C(C(O[C@H](C)C6)=O)C6=C5)=C2OC)=O)C(C3=O)=CC=C1—
91376-7AMK51286.1?—
1376-6
from: 1376-6
OC1=C(C(C2=C3C(O)=C4C([C@H](O)CC5=C4C(O)=C(C(O[C@@H](C)C6)=O)C6=C5)=C2OC)=O)C(C3=O)=CC=C1—
101376(3)?—
1376-7
from: 1376-7
OC1=C(C(C2=C3C(O)=C4C(CCC5=C4C(O)=C(C(O[C@@H](C)C6)=O)C6=C5)=C2OC)=O)C(C3=O)=CC=C1—
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