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BGC0001370NRPS

Lipopeptide 8D1-1;Lipopeptide 8D1-2

Producing organism
Streptomyces rochei
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces rochei group
Biosynthetic class
NRPS (Type I)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗
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C66H82N14O271502.55 Da

Gene Cluster Map44 genes · 79,876 bp

AAAAAAAA20 kb79.9 kb visible · 79,876 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
EREnoylreductase (ER)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
AmTAminotransferase I/II
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1
Start
+?
Step 2M1
cda2PSI
+Serine
Step 3M2
cda2PSI
+Threonine
Step 4M3
cda2PSI
+Trpytophan
Step 5M4
cda2PSI
+Asparagine
Step 6M5
cda2PSI
+Asparagine
Step 7M6
cda2PSI
+4-hydroxyphenyl-g…
Step 8M7
cda2PS2
+Asparagine
Step 9M8
cda2PS2
+Glycine
Step 10M9
cda2PS2
+3-hydroxyasparagi…
Step 11M10
cda2PS3
+Glutamic acid
Step 12M11
cda2PS3
+Trpytophan
Step 13TE
cda2PS3
Step 14TE
cda2PS3
Step 15TE
cda2PS3
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11370-1Start—
?
OC(C1C([R]1)CCC)=O—
21370-2cda2PSIM1
Serine;1370-1
from: 1370-1
OC(C(NC(C1C([R]1)CCC)=O)CO)=O—
31370-3cda2PSIM2
Threonine;1370-2
from: 1370-2
OC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O—
41370-4cda2PSIM3
Trpytophan;1370-3
from: 1370-3
OC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O—
51370-5cda2PSIM4
Asparagine;1370-4
from: 1370-4
OC(C(NC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O—
61370-6cda2PSIM5
Asparagine;1370-5
from: 1370-5
OC(C(NC(C(NC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O)CC(O)=O)=O—
71370-7cda2PSIM6
4-hydroxyphenyl-glycine;1370-6
from: 1370-6
OC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O)CC(O)=O)=O)C4=CC=C(O)C=C4)=O—
81370-8cda2PS2M7
Asparagine;1370-7
from: 1370-7
OC(C(CC(O)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O)CC(O)=O)=O)C4=CC=C(O)C=C4)=O)=O—
91370-9cda2PS2M8
Glycine;1370-8
from: 1370-8
OC(CNC(C(CC(O)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O)CC(O)=O)=O)C4=CC=C(O)C=C4)=O)=O)=O—
101370-10cda2PS2M9
3-hydroxyasparagine;1370-9
from: 1370-9
OC(C(C(O)C(N)=O)NC(CNC(C(CC(O)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O)CC(O)=O)=O)C4=CC=C(O)C=C4)=O)=O)=O)=O—
111370-11cda2PS3M10
Glutamic acid;1370-10
from: 1370-10
OC(C(CCC(O)=O)NC(C(C(O)C(N)=O)NC(CNC(C(CC(O)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O)CC(O)=O)=O)C4=CC=C(O)C=C4)=O)=O)=O)=O)=O—
121370-12cda2PS3M11
Trpytophan;1370-11
from: 1370-11
OC(C(NC(C(CCC(O)=O)NC(C(C(O)C(N)=O)NC(CNC(C(CC(O)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O)CC(O)=O)=O)C4=CC=C(O)C=C4)=O)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O—
131370-13cda2PS3TE
1370-12
from: 1370-12
OC(C(NC(C(CCC(O)=O)NC(C(C(O)C(N)=O)NC(CNC(C(CC(O)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1C([R]1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O)CC(O)=O)=O)C4=CC=C(O)C=C4)=O)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O—
141370(1)cda2PS3TE
1370-12
from: 1370-12
OC(C(NC(C(CCC(O)=O)NC(C(C(O)C(N)=O)NC(CNC(C(CC(O)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1C(O1)CCC)=O)CO)=O)C(C)O)=O)CC2=CCC3=C2C=CC=C3)=O)CC(O)=O)=O)CC(O)=O)=O)C4=CC=C(O)C=C4)=O)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O—
151370(2)cda2PS3TE
1370-12
from: 1370-12
OC(C(NC(C(CCC(O)=O)NC(C(C(O)C(N)=O)NC(CNC(C(CC(O)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(O)C(O)CCC)=O)CO)=O)C(C)O)=O)CC1=CCC2=C1C=CC=C2)=O)CC(O)=O)=O)CC(O)=O)=O)C3=CC=C(O)C=C3)=O)=O)=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O—
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