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BGC0001368NRPS

JBIR-126

Producing organism
Streptomyces sp. NRRL F-4474
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
6
DOI
MIBiG entry
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JBIR-126
C24H30ClN5O7535.18 Da

Gene Cluster Map27 genes · 42,431 bp

ATEACyCACACBELAmTCyA10 kb42.4 kb visible · 42,431 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
CyHeterocyclization (Cy)
BELBeta-elim. lyase
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

6 steps · 5 edges
Step 1
IF33_RS0114785
+Tryptophan
Step 2
IF33_RS0114790, IF33_RS…
Step 3
IF33_RS0114870
+2-methyl-serine
Step 4
IF33_RS0114830, IF33_RS…
+Tambroline
Step 5
IF33_RS0114825
+2-methyl-serine
Step 6TE
IF33_RS0114825
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions6 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11368-1IF33_RS0114785—
Tryptophan
N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(O)=O—
21368-2IF33_RS0114790, IF33_RS0114805—
1368-1
from: 1368-1
OC(C1=CN(C)C2=C1C(O)=CC(Cl)=C2)=O—
31368-3IF33_RS0114870—
1368-2;2-methyl-serine
from: 1368-2
ClC(C=C1O)=CC2=C1C(C3=N[C@@](C(O)=O)(C)CO3)=CN2C—
41368-4IF33_RS0114830, IF33_RS0114835—
1368-3;Tambroline
from: 1368-3
ClC(C=C1O)=CC2=C1C(C3=N[C@@](C(N[C@@H]([C@H]4CCCN4)C(O)=O)=O)(C)CO3)=CN2C—
51368-5IF33_RS0114825—
1368-4;2-methyl-serine
from: 1368-4
ClC(C=C1O)=CC2=C1C(C3=N[C@@](C(N[C@@H]([C@H]4CCCN4)C(N[C@](CO)(C)C(O)=O)=O)=O)(C)CO3)=CN2C—
61368IF33_RS0114825TE
1368-5
from: 1368-5
ClC(C=C1O)=CC2=C1C(C3=N[C@@](C(N[C@@H]([C@H]4CCCN4)C(N[C@](CO)(C)C(O)=O)=O)=O)(C)CO3)=CN2C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture