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BGC0001351NRPS

Cahuitamycin A;Cahuitamycin B;Cahuitamycin C

Producing organism
Streptomyces gandocaensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
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C27H37N7O11635.26 Da

Gene Cluster Map24 genes · 41,608 bp

CyACACAECAECAA10 kb41.6 kb visible · 41,608 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
CcCOM C-term
EEpimerization (E)
CyHeterocyclization (Cy)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

13 steps · 11 edges
Step 1
Start
+Chorismate
Step 3
?
+Acetyl-CoA, Malonyl-CoA
Step 2
cahI
Step 4Load
AMK48225.1
Step 5M1
AMK48225.1
+L-Cysteine
Step 6M2
cahB
+L-Serine
Step 7M3
cahB
+N-hydroxy-ornithi…
Step 8M4
cahC
+D-Piperazic acid
Step 9M5
cahD
+β-Alanine
Step 10
cahG
Step 11
cahG
Step 12
cahG
Step 13
cahG
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11351-1Start—
Chorismate
O=C([O-])C1=C[C@@H](OC(C([O-])=O)=C)[C@H](O)C=C1—
21351-2cahI—
1351-1
from: 1351-1
OC1=CC=CC=C1C([O-])=O—
31351-3?—
Acetyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
OC1=CC=CC(C)=C1C([O-])=O—
41351-4AMK48225.1Loading
1351-2/1351-3
from: 1351-2/1351-3
[R]C1=C(C(O)=O)C(O)=CC=C1—
51351-5AMK48225.1M1
1351-4;L-Cysteine
from: 1351-4
[R]C1=C(C2=N[C@H](C(O)=O)CO2)C(O)=CC=C1—
61351-6cahBM2
1351-5;L-Serine
from: 1351-5
[R]C1=C(C2=N[C@H](C(N[C@@H](CO)C(O)=O)=O)CO2)C(O)=CC=C1—
71351-7cahBM3
1351-6;N-hydroxy-ornithine
from: 1351-6
[R]C1=C(C2=N[C@H](C(N[C@@H](CO)C(N[C@H](CCCN(O)C([H])=O)C(O)=O)=O)=O)CO2)C(O)=CC=C1—
81351-8cahCM4
1351-7;D-Piperazic acid
from: 1351-7
[R]C1=C(C2=N[C@H](C(N[C@@H](CO)C(N[C@H](CCCN(O)C([H])=O)C(N3NCCC[C@@H]3C(O)=O)=O)=O)=O)CO2)C(O)=CC=C1—
91351-9cahDM5
1351-8;β-Alanine
from: 1351-8
[R]C1=C(C2=N[C@H](C(N[C@@H](CO)C(N[C@H](CCCN(O)C([H])=O)C(N3NCCC[C@@H]3C(NCCC(O)=O)=O)=O)=O)=O)CO2)C(O)=CC=C1—
101351-10cahG—
1351-9
from: 1351-9
[R]C1=C(C2=N[C@H](C(N[C@@H](CO)C(N[C@H](CCCN(O)C([H])=O)C(N3CCCC[C@@H]3C(NCCC(O)=O)=O)=O)=O)=O)CO2)C(O)=CC=C1—
111351(1)cahG—
1351-9
from: 1351-9
[H]C1=C(C2=N[C@H](C(N[C@@H](CO)C(N[C@H](CCCN(O)C([H])=O)C(N3CCCC[C@@H]3C(NCCC(O)=O)=O)=O)=O)=O)CO2)C(O)=CC=C1—
121351(2)cahG—
1351-9
from: 1351-9
CC1=C(C2=N[C@H](C(N[C@@H](CO)C(N[C@H](CCCN(O)C([H])=O)C(N3CCCC[C@@H]3C(NCCC(O)=O)=O)=O)=O)=O)CO2)C(O)=CC=C1—
131351(3)cahG—
1351-9
from: 1351-9
[H]C1=C(/C(C)=N/[C@H](C(N[C@@H](CO)C(N[C@H](CCCN(O)C([H])=O)C(N2CCCC[C@@H]2C(NCCC(O)=O)=O)=O)=O)=O)CO)C(O)=CC=C1—
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