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BGC0001348PKS

JBIR-100

Producing organism
Streptomyces varsoviensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
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JBIR-100
C38H58O10674.40 Da

Gene Cluster Map18 genes · 70,801 bp

KSKSKSKSKSKSKSKSKSKSKSKSKS10 kb70.8 kb visible · 70,801 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1Load
IF55_RS40995
+Isobutryl-CoA
Step 2M1
IF55_RS40995;IF55_RS323…
+Methylmalonyl-CoA
Step 3M2
IF55_RS32365
+Malonyl-CoA
Step 4M3
IF55_RS32365
+Methylmalonyl-CoA
Step 5M4
IF55_RS32370
+Methylmalonyl-CoA
Step 6M5
IF55_RS32370
+Methoxymalonyl-ACP
Step 7M6
IF55_RS32370
+Malonyl-CoA
Step 8M7
IF55_RS32375
+Methylmalonyl-CoA
Step 9M8
IF55_RS32375
+Methylmalonyl-CoA
Step 10M9
IF55_RS41000
+Methylmalonyl-CoA
Step 11M10
IF55_RS41000
+Methylmalonyl-CoA
Step 12M11
IF55_RS32385
+Methylmalonyl-CoA
Step 13TE
IF55_RS32385, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11348-1IF55_RS40995Loading
Isobutryl-CoA
OC(C(C)C)=O—
21348-2IF55_RS40995;IF55_RS32365M1
1348-1;Methylmalonyl-CoA
from: 1348-1
OC([C@@H]([C@@H](C(C)C)O)C)=O—
31348-3IF55_RS32365M2
1348-2;Malonyl-CoA
from: 1348-2
OC(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O—
41348-4IF55_RS32365M3
1348-3;Methylmalonyl-CoA
from: 1348-3
OC([C@@H](C(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O)C)=O—
51348-5IF55_RS32370M4
1348-4;Methylmalonyl-CoA
from: 1348-4
OC([C@H]([C@H]([C@@H](C(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O)C)O)C)=O—
61348-6IF55_RS32370M5
1348-5;Methoxymalonyl-ACP
from: 1348-5
CO[C@H]([C@@H]([C@H]([C@H]([C@@H](C(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O)C)O)C)O)C(O)=O—
71348-7IF55_RS32370M6
1348-6;Malonyl-CoA
from: 1348-6
CO[C@H]([C@@H]([C@H]([C@H]([C@@H](C(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O)C)O)C)O)/C=C/C(O)=O—
81348-8IF55_RS32375M7
1348-7;Methylmalonyl-CoA
from: 1348-7
OC(/C(C)=C/C=C/[C@@H]([C@@H]([C@H]([C@H]([C@@H](C(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O)C)O)C)O)OC)=O—
91348-9IF55_RS32375M8
1348-8;Methylmalonyl-CoA
from: 1348-8
OC([C@H](C/C(C)=C/C=C/[C@@H]([C@@H]([C@H]([C@H]([C@@H](C(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O)C)O)C)O)OC)C)=O—
101348-10IF55_RS41000M9
1348-9;Methylmalonyl-CoA
from: 1348-9
C[C@@H]([C@H]([C@H](C/C(C)=C/C=C/[C@@H]([C@@H]([C@H]([C@H]([C@@H](C(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O)C)O)C)O)OC)C)O)C(O)=O—
111348-11IF55_RS41000M10
1348-10;Methylmalonyl-CoA
from: 1348-10
C/C(C(O)=O)=C\[C@H]([C@H]([C@H](C/C(C)=C/C=C/[C@@H]([C@@H]([C@H]([C@H]([C@@H](C(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O)C)O)C)O)OC)C)O)C—
121348-12IF55_RS32385M11
1348-12;Methylmalonyl-CoA
from: 1348-12
O=C(O)/C(C)=C/C(C)=C/[C@H]([C@H]([C@H](C/C(C)=C/C=C/[C@@H]([C@@H]([C@H]([C@H]([C@@H](C(C[C@H]([C@@H]([C@@H](C(C)C)O)C)O)=O)C)O)C)O)OC)C)O)C—
131348IF55_RS32385, ?TE
1348-12
from: 1348-12
C[C@@H]1[C@@H](C(C)C)O[C@]([C@H]([C@@H]([C@@H]([C@H]([C@@H](OC)/C=C/C=C2C)OC(/C(C)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C\2)=O)C)O)C)(O)C[C@H]1OC(/C=C/C(O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture