NPdia

BGC0001332Hybrid

Microtermolide A

Producing organism: Streptomyces sp. MspMP-M5
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I);PKS (Unknown)
Total steps: 8
DOI: 10.1186/s40793-016-0206-2 10.1038/nchem.2657
MIBiG entry: View on MIBiG ↗

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microtermolide A

C₂₃H₃₇N₃O₆451.27 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Other

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Thioesterase (TE)

Epimerization (E)

Dehydratase (DH2)

Aminotransferase III

TIGR01720

8 steps · 7 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1332-1`	B073_RS40860	—	?	`O=C(O)CC[H]`	—
2	`1332-2`	B073_RS40860	—	1332-1;Methylmalonyl-CoA from: 1332-1	`[H]CCCC(C)C(O)=O`	—
3	`1332-3`	B073_RS0123885	—	1332-2;Hydroxyethylmalonyl-CoA from: 1332-2	`[H]CCCC(C)C(O)C(CCO)C(O)=O`	{'Missing':['KR']}
4	`1332-4`	B073_RS0123880	—	1332-3;Serine from: 1332-3	`[H]CCCC(C)C(O)C(CCO)C(NC(CO)C(O)=O)=O`	—
5	`1332-5`	B073_RS0123875	—	1332-4;Malonyl-CoA from: 1332-4	`[H]CCCC(C)C(O)C(CCO)C(NC(/C=C/C(O)=O)=C)=O`	—
6	`1332-6`	B073_RS0123900	—	1332-5;Glycine from: 1332-5	`[H]CCCC(C)C(O)C(CCO)C(NC(/C=C/C(NCC(O)=O)=O)=C)=O`	—
7	`1332-7`	B073_RS0123900	—	1332-6;Valine from: 1332-6	`[H]CCCC(C)C(O)C(CCO)C(NC(/C=C/C(NCC(NC(C(O)=O)C(C)C)=O)=O)=C)=O`	—
8	`1332`	?	—	1332-7 from: 1332-7	`CC(C)C(C1=O)NC(CNC(/C=C/C(NC(C(CCO)C(C(CCC[H])C)O1)=O)=C)=O)=O`	—

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