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BGC0001330Hybrid

BE-43547A1;BE-43547A2;BE-43547B1;BE-43547B2;BE-43547B3;BE-43547C1;BE-43547C2

Producing organism
Micromonospora sp. RV43
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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C30H49N3O7563.36 Da

Gene Cluster Map20 genes · 43,587 bp

ACALKSATKSCACAKSATDH2CAMTCTE10 kb43.6 kb visible · 43,587 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
ABD52_RS02395
+?
Step 2M1
ABD52_RS02395
+Methylmalonyl-CoA
Step 3M2
ABD52_RS02400
+Methylmalonyl-CoA
Step 4M3
ABD52_RS02405
+Glycine
Step 5M4
ABD52_RS02405
+Serine
Step 6M5
ABD52_RS02410
+Malonyl-CoA
Step 7M6
ABD52_RS02415
+Glycine
Step 8TE
ABD52_RS02420
Step 9
?
Step 10
?
Step 11
?
Step 12
?
Step 13
?
Step 14
?
Step 15
?
Step 16
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11330-1ABD52_RS02395Loading
?
O=C([R])O—
21330-2ABD52_RS02395M1
1330-1;Methylmalonyl-CoA
from: 1330-1
OC([R])[C@@H](C(O)=O)C—
31330-3ABD52_RS02400M2
1330-2;Methylmalonyl-CoA
from: 1330-2
OC([R])[C@@H](C([C@H](C(O)=O)C)=O)C—
41330-4ABD52_RS02405M3
1330-3;Glycine
from: 1330-3
OC([R])[C@@H](C([C@H](C(NCC(O)=O)=O)C)=O)C—
51330-5ABD52_RS02405M4
1330-4;Serine
from: 1330-4
OC([R])[C@@H](C([C@H](C(NCC(N[C@H](C(O)=O)CO)=O)=O)C)=O)C—
61330-6ABD52_RS02410M5
1330-5;Malonyl-CoA
from: 1330-5
OC([R])[C@@H](C([C@H](C(NCC(NC(/C=C/C(O)=O)=C)=O)=O)C)=O)C—
71330-7ABD52_RS02415M6
1330-6;Glycine
from: 1330-6
OC([R])[C@@H](C([C@H](C(NCC(NC(/C=C/C(N(C)CC(O)=O)=O)=C)=O)=O)C)=O)C—
81330-8ABD52_RS02420TE
1330-7
from: 1330-7
C=C(/C=C/C1=O)NC(CNC([C@H](C)C([C@@H](C)[C@@H](OC(CN1C)=O)[R])=O)=O)=O—
91330-9?—
1330-8
from: 1330-8
C=C(/C=C/C1=O)NC(CNC([C@@](C)(O)C([C@@H](C)[C@@H](OC(CN1C)=O)[R])=O)=O)=O—
101330(1)?—
1330-8
from: 1330-8
C=C(/C=C/C1=O)NC(CNC([C@@](C)(O)C([C@@H](C)[C@H](CCCCCCCCCCC(C)C)OC(CN1C)=O)=O)=O)=O—
111330(2)?—
1330-8
from: 1330-8
C=C(/C=C/C1=O)NC(CNC([C@@](C)(O)C([C@@H](C)[C@H](CCCCCCCCCCCCC)OC(CN1C)=O)=O)=O)=O—
121330(3)?—
1330-8
from: 1330-8
C=C(/C=C/C1=O)NC(CNC([C@@](C)(O)C([C@@H](C)[C@H](CCCCCCCCCCC(C)CC)OC(CN1C)=O)=O)=O)=O—
131330(4)?—
1330-8
from: 1330-8
C=C(/C=C/C1=O)NC(CNC([C@@](C)(O)C([C@@H](C)[C@H](CCCCCCCCCCCC(C)C)OC(CN1C)=O)=O)=O)=O—
141330(5)?—
1330-8
from: 1330-8
C=C(/C=C/C1=O)NC(CNC([C@@](C)(O)C([C@@H](C)[C@H](CCCCCCCCCCCCCC)OC(CN1C)=O)=O)=O)=O—
151330(6)?—
1330-8
from: 1330-8
C=C(/C=C/C1=O)NC(CNC([C@@](C)(O)C([C@@H](C)[C@H](CCCCCCCCCCCCCCC)OC(CN1C)=O)=O)=O)=O—
161330(7)?—
1330-8
from: 1330-8
C=C(/C=C/C1=O)NC(CNC([C@@](C)(O)C([C@@H](C)[C@H](CCCCCCCCCCCCC(C)C)OC(CN1C)=O)=O)=O)=O—
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