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BGC0001329Hybrid

Rakicidin D

Producing organism
Streptomyces lilacinus
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
9
DOI
MIBiG entry
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rakicidin D
C24H38N4O7494.27 Da

Gene Cluster Map19 genes · 36,804 bp

ERKRKSATKRCAKSKRACTECATauD5 kb36.8 kb visible · 36,804 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

9 steps · 8 edges
Step 1
?
+Hexanoic acid
Step 2
?;ctg1_orf1;ctg1_orf2
+Methylmalonyl-CoA
Step 3
ctg1_orf3
+Methylmalonyl-CoA
Step 4
ctg1_orf4
+Serine
Step 5
ctg1_orf5
+Malonyl-CoA
Step 6
?
+Glycine
Step 7
?
+Asparagine
Step 8
?
Step 9
?
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11329-1?
Hexanoic acid
O=C(CCCCC[H])O
21329-2?;ctg1_orf1;ctg1_orf2
1329-1;Methylmalonyl-CoA
from: 1329-1
CC(C(O)=O)CCCCCC[H]
31329-3ctg1_orf3
1329-2;Methylmalonyl-CoA
from: 1329-2
CC(C(O)C(C(O)=O)C)CCCCCC[H]
41329-4ctg1_orf4
1329-3;Serine
from: 1329-3
CC(C(O)C(C(NC(C(O)=O)CO)=O)C)CCCCCC[H]
51329-5ctg1_orf5
1329-4;Malonyl-CoA
from: 1329-4
CC(C(O)C(C(NC(/C=C/C(O)=O)=C)=O)C)CCCCCC[H]
61329-6?
1329-5;Glycine
from: 1329-5
CC(C(O)C(C(NC(/C=C/C(N(CC(O)=O)C)=O)=C)=O)C)CCCCCC[H]
71329-7?
1329-6;Asparagine
from: 1329-6
CC(C(O)C(C(NC(/C=C/C(N(CC(NC(C(O)=O)CC(N)=O)=O)C)=O)=C)=O)C)CCCCCC[H]
81329-8?
1329-7
from: 1329-7
C=C(/C=C/C(N(CC(NC1CC(N)=O)=O)C)=O)NC(C(C)C(C(CCCCCC[H])C)OC1=O)=O
91329?
1329-8
from: 1329-8
C=C(/C=C/C(N(CC(NC1C(O)C(N)=O)=O)C)=O)NC(C(C)C(C(CCCCCC[H])C)OC1=O)=O
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture