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BGC0001327Hybrid

Rakicidin A;Rakicidin B

Producing organism
Micromonospora purpureochromogenes
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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C32H54N4O7606.40 Da

Gene Cluster Map10 genes · 38,418 bp

CALKSATERKSATKRCAKSATKRDH2CAMTCACTECA10 kb38.4 kb visible · 38,418 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase
CALCoA-ligase (CAL)
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1
IH31_RS0100575
+?
Step 2
IH31_RS0100575
+Methylmalonyl-CoA
Step 3
IH31_RS34685
+Methylmalonyl-CoA
Step 4
IH31_RS0100585
+Serine
Step 5
IH31_RS0100590
+Malonyl-CoA
Step 6
IH31_RS0100595
+Glycine
Step 7
IH31_RS0100600
+Asparagine
Step 8
?
Step 9
IH31_RS0100620
Step 10
IH31_RS0100620
Step 11
IH31_RS0100620
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11327-1IH31_RS0100575—
?
O=C([R])O—
21327-2IH31_RS0100575—
1327-1;Methylmalonyl-CoA
from: 1327-1
[R]CC(C(O)=O)C—
31327-3IH31_RS34685—
1327-2;Methylmalonyl-CoA
from: 1327-2
[R]CC(C(O)C(C(O)=O)C)C—
41327-4IH31_RS0100585—
1327-3;Serine
from: 1327-3
[R]CC(C(O)C(C(NC(C(O)=O)CO)=O)C)C—
51327-5IH31_RS0100590—
1327-4;Malonyl-CoA
from: 1327-4
[R]CC(C(O)C(C(NC(/C=C/C(O)=O)=C)=O)C)C—
61327-6IH31_RS0100595—
1327-5;Glycine
from: 1327-5
[R]CC(C(O)C(C(NC(/C=C/C(N(CC(O)=O)C)=O)=C)=O)C)C—
71327-7IH31_RS0100600—
1327-6;Asparagine
from: 1327-6
[R]CC(C(O)C(C(NC(/C=C/C(N(CC(NC(C(O)=O)CC(N)=O)=O)C)=O)=C)=O)C)C—
81327-8?—
1327-7
from: 1327-7
C=C(/C=C/C(N(CC(NC1C(N)=O)=O)C)=O)NC(C(C)C(C(C[R])C)OC1=O)=O—
91327-9IH31_RS0100620—
1327-8
from: 1327-8
C=C(/C=C/C(N(CC(NC1C(O)C(N)=O)=O)C)=O)NC(C(C)C(C(C[R])C)OC1=O)=O—
101327(1)IH31_RS0100620—
1327-8
from: 1327-8
C=C(/C=C/C(N(CC(NC1C(C(N)=O)O)=O)C)=O)NC(C(C)C(C(CCCCCCCCCCCC(C)C)C)OC1=O)=O—
111327(2)IH31_RS0100620—
1327-8
from: 1327-8
C=C(/C=C/C(N(CC(NC1C(C(N)=O)O)=O)C)=O)NC(C(C)C(C(CCCCCCCCCCCCC(C)C)C)OC1=O)=O—
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