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BGC0001303PKS

Lobosamide A;Lobosamide B;Lobosamide C

Producing organism
Micromonospora sp. RL09-050-HVF-A
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
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C29H41NO5483.30 Da

Gene Cluster Map46 genes · 108,672 bp

20 kb108.7 kb visible · 108,672 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
CycPolyketide cyclase
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1
Start
+Glutamic acid
Step 2
lobP
Step 3
lobO
Step 4
lobL;lobK
Step 5
lobM
Step 6Load
lobN;lobR
Step 7M1
lobR
+Malonyl-CoA
Step 8M2
lobR
+Methylmalonyl-CoA
Step 9M3
lobR
+Methylmalonyl-CoA
Step 10M4
lobR
+Malonyl-CoA
Step 11M5
lobA
+Malonyl-CoA
Step 12M6
lobB
+Malonyl-CoA
Step 13M7
lobB
+Malonyl-CoA
Step 14M8
lobC
+Methylmalonyl-CoA
Step 15M9
lobD
+Malonyl-CoA
Step 16M10
lobD;lobE
+Malonyl-CoA
Step 17M11
lobE;lobF
+Malonyl-CoA
Step 18
lobG
Step 19TE
lobF
Step 20
lobQ
+1303(1)
Step 21
?
+1303(2)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11303-1Start—
Glutamic acid
O=C(CC[C@@H](C(O)=O)N)O—
21303-2lobP—
1303-1
from: 1303-1
O=C(CC(N)CC(O)=O)O—
31303-3lobO—
1303-2
from: 1303-2
O=C(C[C@@H](N)C)O—
41303-4lobL;lobK—
1303-3
from: 1303-3
O=C(C[C@@H](N)C)O—
51303-5lobM—
1303-4
from: 1303-4
O=C(C[C@@H](NC([R])=O)C)O—
61303-6lobN;lobRLoading
1303-5
from: 1303-5
OC(C[C@H](C)NC([R])=O)=O—
71303-7lobRM1
1303-6;Malonyl-CoA
from: 1303-6
C[C@@H](C/C=C/C(O)=O)NC([R])=O—
81303-8lobRM2
1303-7;Methylmalonyl-CoA
from: 1303-7
C[C@@H](C/C=C/C=C(C(O)=O)\C)NC([R])=O—
91303-9lobRM3
1303-8;Methylmalonyl-CoA
from: 1303-8
C[C@@H](C/C=C/C=C(/C=C(C(O)=O)\C)C)NC([R])=O—
101303-10lobRM4
1303-9;Malonyl-CoA
from: 1303-9
C[C@@H](C/C=C/C=C(/C=C(/C=C/C(O)=O)C)C)NC([R])=O—
111303-11lobAM5
1303-10;Malonyl-CoA
from: 1303-10
C[C@@H](C/C=C/C=C(/C=C(/C=C/C=C\C(O)=O)C)C)NC([R])=O—
121303-12lobBM6
1303-11;Malonyl-CoA
from: 1303-11
C[C@@H](C/C=C/C=C(/C=C(/C=C/C=C\[C@H](O)CC(O)=O)C)C)NC([R])=O—
131303-13lobBM7
1303-12;Malonyl-CoA
from: 1303-12
C[C@@H](C/C=C/C=C(/C=C(/C=C/C=C\[C@H](O)C[C@H](O)CC(O)=O)C)C)NC([R])=O—
141303-14lobCM8
1303-13;Methylmalonyl-CoA
from: 1303-13
C[C@@H](C/C=C/C=C(/C=C(/C=C/C=C\[C@H](O)C[C@H](O)C[C@H](O)[C@@H](C)C(O)=O)C)C)NC([R])=O—
151303-15lobDM9
1303-14;Malonyl-CoA
from: 1303-14
C[C@@H](C/C=C/C=C(/C=C(/C=C/C=C\[C@H](O)C[C@H](O)C[C@H](O)[C@@H](C)/C=C/C(O)=O)C)C)NC([R])=O—
161303-16lobD;lobEM10
1303-15;Malonyl-CoA
from: 1303-15
C[C@@H](C/C=C/C=C(/C=C(/C=C/C=C\[C@H](O)C[C@H](O)C[C@H](O)[C@@H](C)/C=C/C=C/C(O)=O)C)C)NC([R])=O—
171303-17lobE;lobFM11
1303-16;Malonyl-CoA
from: 1303-16
C[C@@H](C/C=C/C=C(/C=C(/C=C/C=C\[C@H](O)C[C@H](O)C[C@H](O)[C@@H](C)/C=C/C=C/C=C/C(O)=O)C)C)NC([R])=O—
181303-18lobG—
1303-17
from: 1303-17
N[C@@H](C)C/C=C/C=C(/C=C(/C=C/C=C\[C@H](O)C[C@H](O)C[C@H](O)[C@@H](C)/C=C/C=C/C=C/C(O)=O)C)C—
191303(1)lobFTE
1303-18
from: 1303-18
O[C@H](C[C@H](O)[C@@H](C)/C=C/C=C/C=C/1)C[C@@H](O)/C=C\C=C\C(C)=C\C(C)=C\C=C\C[C@H](C)NC1=O—
201303(2)lobQ—
1303(1)
O[C@H]([C@@H](O)[C@H](O)[C@@H](C)/C=C/C=C/C=C/1)C[C@@H](O)/C=C\C=C\C(C)=C\C(C)=C\C=C\C[C@H](C)NC1=O—
211303(3)?—
1303(2)
O[C@H]([C@H]1O)[C@@H]([C@H](/C=C/C=C/C=C/C(N[C@H](C/C=C/C=C(/C=C(/C=C/C=C\[C@@H](C1)O)C)C)C)=O)C)O—
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