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BGC0001301PKS

Anthracimycin

Producing organism
Streptomyces sp. T676
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map9 genes · 53,253 bp

ATATKSKSKSERKSKSKSKSKSKSKSTE10 kb53.3 kb visible · 53,253 bp total
Biosynthetic (core)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1
Start
+Malonyl-CoA
Step 2M1
atcD
Step 3M2
atcD
Trans-AT
Step 4M3
atcD
Trans-AT
Step 5M4
atcD;atcE
Trans-AT
Step 6M5
atcE
Trans-AT
Step 7M6;7
atcE
Trans-AT
Step 8M7
atcE
Trans-AT
Step 9M8
atcF
Trans-AT
Step 10M9
atcF
Trans-AT
Step 11M10
atcF
Trans-AT
Step 12TE
atcF
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11301-1Start—
Malonyl-CoA
O=C(O)CC([R])=O—
21301-2atcDM1
1301-1
from: 1301-1
O=C(C[C@@](O)([H])C)O—
31301-3atcDM2
1301-2
from: 1301-2
C[C@](O)([H])/C=C/CC(O)=O{'transAT': ['atcC', 'Malony…
41301-4atcDM3
1301-3
from: 1301-3
C[C@](O)([H])/C=C/C=C\[C@H](C)C(O)=O{'transAT': ['atcC', 'Malony…
51301-5atcD;atcEM4
1301-4
from: 1301-4
C[C@](O)([H])/C=C/C=C\[C@H](C)/C=C/C(O)=O{'transAT': ['atcC', 'Malony…
61301-6atcEM5
1301-5
from: 1301-5
C[C@](O)([H])/C=C/C=C\[C@H](C)/C=C/C=C/C(O)=O{'transAT': ['atcC', 'Malony…
71301-7atcEM6;7
1301-6
from: 1301-6
C[C@](O)([H])/C=C/C=C\[C@H](C)/C=C/C=C/CC(C)C(O)=O{'transAT': ['atcC', 'Malony…
81301-8atcEM7
1301-7
from: 1301-7
C[C@](O)([H])/C=C/C=C\[C@H](C)/C=C/C=C/C/C(C)=C\CC(O)=O{'transAT': ['atcC', 'Malony…
91301-9atcFM8
1301-8
from: 1301-8
C[C@](O)([H])/C=C/C=C\[C@H](C)[C@@]1([H])C=C[C@@]2([H])CC(C)=CC[C@]2([H])[C@@]1([H])C(O)=O{'transAT': ['atcC', 'Malony…
101301-10atcFM9
1301-9
from: 1301-9
C[C@](O)([H])/C=C/C=C\[C@H](C)[C@@]1([H])C=C[C@@]2([H])CC(C)=CC[C@]2([H])[C@@]1([H])C(CC(O)=O)O{'transAT': ['atcC', 'Malony…
111301-11atcFM10
1301-10
from: 1301-10
C[C@](O)([H])/C=C/C=C\[C@H](C)[C@@]1([H])C=C[C@@]2([H])CC(C)=CC[C@]2([H])[C@@]1([H])/C(O)=C/C([C@@H](C)C(O)=O)=O{'transAT': ['atcC', 'Malony…
121301atcFTE
1301-11
from: 1301-11
O=C([C@@H]1C)O[C@H](C)/C=C/C=C\[C@H]([C@]2([H])[C@]([C@](CC=C(C)C3)([H])[C@@]3([H])C=C2)([H])/C(O)=C/C1=O)C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture