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BGC0001300PKS

Anthracimycin

Producing organism
Streptomyces sp. CNH365
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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anthracimycin
C25H32O4396.23 Da

Gene Cluster Map15 genes · 59,810 bp

KSKSKSERKSKSKSKSKSKSKS10 kb59.8 kb visible · 59,810 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1M1
atcD
+3-hydroxybutyryl-…
Step 2M2
atcD
Trans-AT
Step 3M3
atcD
Trans-AT
Step 4M4
atcD;atcE
Trans-AT
Step 5M5
atcE
Trans-AT
Step 6M6;7
atcE
Trans-AT
Step 7M7
atcE
Inactive: atcC, Malonyl-CoA
Step 8M8
atcF
Trans-AT
Step 9M9
atcF
Trans-AT
Step 10M10
atcF
Trans-AT
Step 11TE
atcF
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11300-1atcDM1
3-hydroxybutyryl-coa
O=C(O)CC(O)C—
21300-2atcDM2
1300-1
from: 1300-1
CC(O)C/C=C/C(O)=O{'transAT': ['atcC', 'Malony…
31300-3atcDM3
1300-2
from: 1300-2
OC(C(C)/C=C\C=C\C(O)C)=O{'transAT': ['atcC', 'Malony…
41300-4atcD;atcEM4
1300-3
from: 1300-3
CC(/C=C\C=C\C(O)C)/C=C/C(O)=O{'transAT': ['atcC', 'Malony…
51300-5atcEM5
1300-4
from: 1300-4
CC(/C=C\C=C\C(O)C)/C=C/C=C/C(O)=O{'transAT': ['atcC', 'Malony…
61300-6atcEM6;7
1300-5
from: 1300-5
CC(/C=C\C=C\C(O)C)/C=C/C=C/CC(C)C(O)=O{'transAT': ['atcC', 'Malony…
71300-7atcEM7
1300-6
from: 1300-6
C/C(C/C=C/C=C/C(C)/C=C\C=C\C(O)C)=C/CC(O)=O{'transAT': ['atcC', 'Malony…
81300-8atcFM8
1300-7
from: 1300-7
OC(C)/C=C/C=C\C(C)C1C=CC(CC(C)=CC2)C2C1C(O)=O{'transAT': ['atcC', 'Malony…
91300-9atcFM9
1300-8
from: 1300-8
OC(C)/C=C/C=C\C(C)C1C=CC(CC(C)=CC2)C2C1C(CC(O)=O)=O{'transAT': ['atcC', 'Malony…
101300-10atcFM10
1300-9
from: 1300-9
OC(C)/C=C/C=C\C(C)C1C=CC(CC(C)=CC2)C2C1C(CC(C(C)C(O)=O)=O)=O{'transAT': ['atcC', 'Malony…
111300atcFTE
1300-10
from: 1300-10
O=C([C@@H]1C)O[C@H](C)/C=C/C=C\[C@H]([C@]2([H])[C@]([C@](CC=C(C)C3)([H])[C@@]3([H])C=C2)([H])/C(O)=C/C1=O)C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture