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BGC0001298PKS

4-Z-annimycin;4-E-annimycin

Producing organism
Streptomyces calvus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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C19H25NO4331.18 Da

Gene Cluster Map9 genes · 41,001 bp

AAmTAKSATKSATKSATKSATKSATKSATTE10 kb41 kb visible · 41,001 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

17 steps · 17 edges
Step 1Load
AGY30676.1
+Propionyl-CoA
Step 11
Start
Step 12
Start
Step 2M1
AGY30676.1
+Malonyl-CoA
Step 13
AGY30678.1
Step 3M2
AGY30676.1
+Methylmalonyl-CoA
Step 14
AGY30675.1
Step 4M3
AGY30676.1
+Malonyl-CoA
Step 15
AGY30678.1
Step 5M4
AGY30676.1
+Malonyl-CoA
Step 6M4
AGY30676.1
+Malonyl-CoA
Step 7M5
AGY30676.1
+Malonyl-CoA
Inactive: DH
Step 8M5
AGY30676.1
+Malonyl-CoA
Inactive: DH
Step 9TE
AGY30676.1
Step 10TE
AGY30676.1
Step 16
AGY30674.1
Step 17
AGY30674.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11298-1AGY30676.1Loading
Propionyl-CoA
O=C(O)CC—
21298-2AGY30676.1M1
1298-1;Malonyl-CoA
from: 1298-1
CC/C=C/C(O)=O—
31298-3AGY30676.1M2
1298-2;Methylmalonyl-CoA
from: 1298-2
CC/C=C/C=C(C)/C(O)=O—
41298-4AGY30676.1M3
1298-3;Malonyl-CoA
from: 1298-3
CC/C=C/C=C(C)/C=C/C(O)=O—
51298-5AGY30676.1M4
1298-4;Malonyl-CoA
from: 1298-4
CC/C=C/C=C(C)/C=C/C=C\C(O)=O—
61298-6AGY30676.1M4
1298-4;Malonyl-CoA
from: 1298-4
CC/C=C/C=C(C)/C=C/C=C/C(O)=O—
71298-7AGY30676.1M5
1298-5;Malonyl-CoA
from: 1298-5
CC/C=C/C=C(C)/C=C/C=C\C(O)CC(O)=O{'Inactive': ['DH']}
81298-8AGY30676.1M5
1298-6;Malonyl-CoA
from: 1298-6
CC/C=C/C=C(C)/C=C/C=C/C(O)CC(O)=O{'Inactive': ['DH']}
91298-9AGY30676.1TE
1298-7
from: 1298-7
CC/C=C/C=C(C)/C=C/C=C\C(O)CC(O)=O—
101298-10AGY30676.1TE
1298-8
from: 1298-8
CC/C=C/C=C(C)/C=C/C=C/C(O)CC(O)=O—
111298-11Start—
O=C(O)CN—
121298-12Start—
O=C(CCC(O)=O)C[R]—
131298-13AGY30678.1—
1298-11;1298-12
from: 1298-11, 1298-12
O=C(CCC(O)=O)CN—
141298-14AGY30675.1—
1298-13
from: 1298-13
O=C(CCC([R])=O)CN—
151298-15AGY30678.1—
1298-14
from: 1298-14
O=C1CCC(O)=C1N—
161298-16AGY30674.1—
1298-9;1298-15
from: 1298-9, 1298-15
CC/C=C/C=C(C)/C=C/C=C\C(O)CC(NC1=C(O)CCC1=O)=O—
171298-17AGY30674.1—
1298-10;1298-15
from: 1298-10, 1298-15
CC/C=C/C=C(C)/C=C/C=C/C(O)CC(NC1=C(O)CCC1=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture