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BGC0001297NRPS

WS9326A;WS9326C;WS9326D

Producing organism
Streptomyces calvus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗
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C54H68N8O131036.49 Da

Gene Cluster Map40 genes · 55,539 bp

KSAACCACACAECACA10 kb55.5 kb visible · 55,539 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1M1
cal17
Step 2M2
cal17
+Tyrosine
Step 3
cal16
Step 4M3
cal18
+Leucine
Step 5M4
cal18
+Phenylalanine
Step 6M5
cal22
+Threonine
Step 7M6
cal23
+Asparagine
Step 8
?
Step 9M7
cal19
+Serine
Step 10TE
cal19
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11297-1cal17M1
OC(C(C(C)O)NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)=O—
21297-2cal17M2
1297-1;Tyrosine
from: 1297-1
O=C(NC(CC1=CC=C(O)C=C1)C(O)=O)C(C(C)O)NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O—
31297-3cal16—
1297-2
from: 1297-2
O=C(N(C)/C(C(O)=O)=C/C1=CC=C(O)C=C1)C(C(C)O)NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O—
41297-4cal18M3
1297-3;Leucine
from: 1297-3
O=C(N(C)/C(C(NCC(C(O)=O)CC(C)C)=O)=C/C1=CC=C(O)C=C1)C(C(C)O)NC(/C=C/C2=CC=CC=C2/C=C\CCC)=O—
51297-5cal18M4
1297-4;Phenylalanine
from: 1297-4
O=C(N(C)/C(C(NCC(C(NC(C(O)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)=C/C2=CC=C(O)C=C2)C(C(C)O)NC(/C=C/C3=CC=CC=C3/C=C\CCC)=O—
61297-6cal22M5
1297-5;Threonine
from: 1297-5
O=C(N(C)/C(C(NCC(C(NC(C(NC(C(O)C)C(O)=O)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)=C/C2=CC=C(O)C=C2)C(C(C)O)NC(/C=C/C3=CC=CC=C3/C=C\CCC)=O—
71297-7cal23M6
1297-6;Asparagine
from: 1297-6
O=C(N(C)/C(C(NCC(C(NC(C(NC(C(O)C)C(NC(CC(N)=O)C(O)=O)=O)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)=C/C2=CC=C(O)C=C2)C(C(C)O)NC(/C=C/C3=CC=CC=C3/C=C\CCC)=O—
81297(1)?—
1297-7
from: 1297-7
O=C(N(C)/C(C(N[C@@H](CC(C)C)C(N[C@H](CC1=CC=CC=C1)C(N[C@@H](C(O)C)C(O)=O)=O)=O)=O)=C/C2=CC=C(O)C=C2)[C@H]([C@H](C)O)NC(/C=C/C3=CC=CC=C3/C=C\CCC)=O—
91297-8cal19M7
1297-7;Serine
from: 1297-7
O=C(N(C)/C(C(NCC(C(NC(C(NC(C(O)C)C(NC(CC(N)=O)C(NC(C(O)=O)CO)=O)=O)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)=C/C2=CC=C(O)C=C2)C(C(C)O)NC(/C=C/C3=CC=CC=C3/C=C\CCC)=O—
101297(2)cal19TE
1297-8
from: 1297-8
O=C(N(C)/C(C(N[C@@H](CC(C)C)C(N[C@H](CC1=CC=CC=C1)C(N[C@@H](C(O)C)C(N[C@@H](CC(N)=O)C2=O)=O)=O)=O)=O)=C/C3=CC=C(O)C=C3)[C@H]([C@H](C)OC([C@@H](N2)CO)=O)NC(/C=C/C4=CC=CC=C4/C=C\CCC)=O—
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