NPdia

BGC0001293PKS

Cyclizidine

Producing organism: Streptomyces sp. NCIB 11649
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Unknown)
Total steps: 11
DOI: 10.1021/acs.orglett.5b02707
MIBiG entry: View on MIBiG ↗

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cyclizidine

C₁₇H₂₅NO₃291.18 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Docking N-term

Docking C-term

Terminal reductase

Aminotransferase III

11 steps · 10 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1293-1`	cycG;cycF	M1	Methylmalonyl-CoA	`O=C(CC)O`	—
2	`1293-2`	cycF, ?	M2	1293-1;Malonyl-CoA from: 1293-1	`O=C(/C=C/CCO)O`	—
3	`1293-3`	cycE	M3	1293-2;Methylmalonyl-CoA from: 1293-2	`OCC/C=C/C=C(C(O)=O)\C`	—
4	`1293-4`	cycE	M4	1293-3;Malonyl-CoA from: 1293-3	`OCC/C=C/C=C(/C=C/C(O)=O)C`	—
5	`1293-5`	cycD;cycC	M5	1293-4;Methylmalonyl-CoA from: 1293-4	`OCC/C=C/C=C(/C=C/[C@@H](O)[C@H](C(O)=O)C)C`	{'Inactive': ['DH']}
6	`1293-6`	cycC	M6	1293-5;Malonyl-CoA from: 1293-5	`OCC/C=C/C=C(/C=C/[C@@H](O)[C@H](C(CC(O)=O)=O)C)C`	{'Inactive': ['KR']}
7	`1293-7`	cycB	M7	1293-6;Malonyl-CoA from: 1293-6	`OCC/C=C/C=C(/C=C/[C@@H](O)[C@H](C(C[C@@H](O)CC(O)=O)=O)C)C`	{'Inactive': ['DH']}
8	`1293-8`	?	—	1293-7 from: 1293-7	`OCC/C=C/C=C(/C=C/[C@@H](O)[C@H](C(C[C@@H](O)CC(O)=O)=O)C)C`	—
9	`1293-9`	?	—	1293-8 from: 1293-8	`O=C([C@@H](C)[C@H](O)/C=C\C(C)=C\C=C\CCO)C[C@@H](O)CCN`	—
10	`1293-10`	?	—	1293-9 from: 1293-9	`C[C@H]([C@]1([H])C[C@@H](O)CCN1)[C@H](O)/C=C\C(C)=C\C=C\CCO`	—
11	`1293`	?	—	1293-10 from: 1293-10	`CC(/C=C/C1CC1)=C\[C@@H]2[C@@H](O)[C@](C)(O)[C@@]3([H])C2CC[C@H]4[C@@H]3O4`	—

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