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BGC0001288PKS

Maklamicin

Producing organism
Micromonospora sp. GMKU326
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
23
DOI
MIBiG entry
View on MIBiG ↗
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maklamicin
C32H44O6524.31 Da

Gene Cluster Map46 genes · 149,333 bp

20 kb149.3 kb visible · 149,333 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
ACPSACP synthase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

23 steps · 22 edges
Step 1Load
makA1
+Malonyl-CoA
Step 15
Start
Step 2M1
makA1
Inactive: AT, DH
Step 16
makB2;makB3
Step 3M2
makA1
+Malonyl-CoA
Inactive: DH
Step 4M3
makA1
+Methylmalonyl-CoA
Step 5M4
makA1
+Methylmalonyl-CoA
Step 6M5
makA1
+Malonyl-CoA
Step 7M6
makA2
+Methylmalonyl-CoA
Step 8M7
makA2
+Malonyl-CoA
Step 9M8
makA2
+Malonyl-CoA
Step 10M9
makA2
+Methylmalonyl-CoA
Step 11M10
makA3
+Malonyl-CoA
Step 12M11
makA3
+Methylmalonyl-CoA
Step 13M12
makA4
+Malonyl-CoA
Step 14
?
Step 17
makB1
Step 18
?
Step 19
makB4
Step 20
makB5
Step 21
?
Step 22
?
Step 23
makC2
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions23 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11288-1makA1Loading
Malonyl-CoA
O=C(O)C—
21288-2makA1M1
1288-1
from: 1288-1
O=C(O)C{'Inactive': ['AT', 'DH']}
31288-3makA1M2
1288-2;Malonyl-CoA
from: 1288-2
O[C@@H](CC(O)=O)C{'Inactive': ['DH']}
41288-4makA1M3
1288-3;Methylmalonyl-CoA
from: 1288-3
O[C@@H](C/C=C(C)/C(O)=O)C—
51288-5makA1M4
1288-4;Methylmalonyl-CoA
from: 1288-4
O[C@@H](C/C=C(C)/C=C(C)/C(O)=O)C—
61288-6makA1M5
1288-5;Malonyl-CoA
from: 1288-5
O[C@@H](C/C=C(C)/C=C(C)/C=C/C(O)=O)C—
71288-7makA2M6
1288-6;Methylmalonyl-CoA
from: 1288-6
O[C@@H](C/C=C(C)/C=C(C)/C=C/C=C(C)/C(O)=O)C—
81288-8makA2M7
1288-7;Malonyl-CoA
from: 1288-7
O[C@@H](C/C=C(C)/C=C(C)/C=C/C=C(C)/C=C/C(O)=O)C—
91288-9makA2M8
1288-8;Malonyl-CoA
from: 1288-8
O[C@@H](C/C=C(C)/C=C(C)/C=C/C=C(C)/C=C/C=C/C(O)=O)C—
101288-10makA2M9
1288-9;Methylmalonyl-CoA
from: 1288-9
O[C@@H](C/C=C(C)/C=C(C)/C=C/C=C(C)/C=C/C=C/CC(C)C(O)=O)C—
111288-11makA3M10
1288-10;Malonyl-CoA
from: 1288-10
O[C@@H](C/C=C(C)/C=C(C)/C=C/C=C(C)/C=C/C=C/CC(C)CCC(O)=O)C—
121288-12makA3M11
1288-11;Methylmalonyl-CoA
from: 1288-11
O[C@@H](C/C=C(C)/C=C(C)/C=C/C=C(C)/C=C/C=C/CC(C)CC/C=C(C)/C(O)=O)C—
131288-13makA4M12
1288-12;Malonyl-CoA
from: 1288-12
O[C@@H](C/C=C(C)/C=C(C)/C=C/C=C(C)/C=C/C=C/CC(C)CC/C=C(C)/C(CC(O)=O)=O)C—
141288-14?—
1288-13
from: 1288-13
C/C([C@@](C=C[C@]1([H])C[C@@H](C)CC[C@]12[H])([H])[C@@]2(C)C(CC(O)=O)=O)=C\C=C\C(C)=C\C(C)=C\C[C@@H](C)O—
151288-15Start—
O=P([O-])(OCC(C(OP([O-])([O-])=O)=O)O)[O-]—
161288-16makB2;makB3—
1288-15
from: 1288-15
OCC(C(O)=O)O—
171288-17makB1—
1288-14;1288-16
from: 1288-14, 1288-16
C/C([C@@](C=C[C@]1([H])C[C@@H](C)CC[C@]12[H])([H])[C@@]2(C)C(CC(OC(C(O)=O)CO)=O)=O)=C\C=C\C(C)=C\C(C)=C\C[C@@H](C)O—
181288-18?—
1288-17
from: 1288-17
C/C([C@@](C=C[C@]1([H])C[C@@H](C)CC[C@]12[H])([H])[C@@]2(C)C(C3=C(O)C(CO)OC3=O)=O)=C\C=C\C(C)=C\C(C)=C\C[C@@H](C)O—
191288-19makB4—
1288-18
from: 1288-18
C/C([C@@](C=C[C@]1([H])C[C@@H](C)CC[C@]12[H])([H])[C@@]2(C)C(C3=C(O)C(COC(C)=O)OC3=O)=O)=C\C=C\C(C)=C\C(C)=C\C[C@@H](C)O—
201288-20makB5—
1288-19
from: 1288-19
C/C([C@@](C=C[C@]1([H])C[C@@H](C)CC[C@]12[H])([H])[C@@]2(C)C(C(C(O3)=O)=C(O)C3=C)=O)=C\C=C\C(C)=C\C(C)=C\C[C@@H](C)O—
211288-21?—
1288-20
from: 1288-20
CC(/C=C/C/C(C)=C\C(C)=C\C[C@H](O)C)[C@@](C=C[C@]1([H])C[C@@H](C)CC[C@]12[H])([H])[C@@]2(C)C(C(C(O3)=O)=C(O)C3=C)=O—
221288-22?—
1288-21
from: 1288-21
CC(/C=C/C[C@@]1(C=C([C@@H](C2)C[C@H](O)C)C)C)[C@@](C=C[C@]3([H])C[C@@H](C)CC[C@]34[H])([H])[C@@]4(C)C(C5=C(O)[C@@]12OC5=O)=O—
231288makC2—
1288-22
from: 1288-22
CC(/C=C/C[C@@]1(C=C([C@@H](C2)C[C@H](O)C)CO)C)[C@@](C=C[C@]3([H])C[C@@H](C)CC[C@]34[H])([H])[C@@]4(C)C(C5=C(O)[C@@]12OC5=O)=O—
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