NPdia
← Back to Repository
BGC0001287PKS

Chaxamycin A;Chaxamycin B;Chaxamycin C;Chaxamycin D

Producing organism
Streptomyces leeuwenhoekii
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
Loading…
C35H45NO10639.30 Da

Gene Cluster Map29 genes · 78,781 bp

KSKSKSKSKSKSKSCALKSKSKS20 kb78.8 kb visible · 78,781 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1Load
cxmA
+AHBA
Inactive: KR
Step 2M1
cxmA
+Methylmalonyl-CoA
Inactive: DH
Step 3M2
cxmA
+Malonyl-CoA
Inactive: DH
Step 4M3
cxmA
+Methylmalonyl-CoA
Inactive: KR
Step 5
cxm19
Step 6M4
cxmB
+Methylmalonyl-CoA
Step 7M5
cxmB
+Methylmalonyl-CoA
Inactive: DH
Step 8M6
cxmB
+Methylmalonyl-CoA
Inactive: DH
Step 9M7
cxmC
+Methylmalonyl-CoA
Inactive: DH
Step 10M8
cxmD
+Methylmalonyl-CoA
Inactive: DH
Step 11M9
cxmE
+Malonyl-CoA
Step 12M10
cxmE
+Malonyl-CoA
Step 13
cxmF
Step 14
cxm24
Step 15
?
Step 16
cxm24
Step 17
?
+1287(2)
Step 18
cxm20, cxm23
+1287(3)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11287-1cxmALoading
AHBA
OC1=CC(C(O)=O)=CC(N)=C1{'Inactive': ['KR']}
21287-2cxmAM1
1287-1;Methylmalonyl-CoA
from: 1287-1
OC1=CC([C@@H](O)[C@H](C(O)=O)C)=CC(N)=C1{'Inactive': ['DH']}
31287-3cxmAM2
1287-2;Malonyl-CoA
from: 1287-2
OC1=CC([C@@H](O)[C@H](C(CC(O)=O)=O)C)=CC(N)=C1{'Inactive': ['DH']}
41287-4cxmAM3
1287-3;Methylmalonyl-CoA
from: 1287-3
OC1=CC([C@@H](O)[C@H](C(CC([C@H](C(O)=O)C)=O)=O)C)=CC(N)=C1{'Inactive': ['KR']}
51287-5cxm19—
1287-4
from: 1287-4
O=C1C=C(N)C(C([C@@H](O)[C@H](C(CC([C@H](C(O)=O)C)=O)=O)C)=C1)=O—
61287-6cxmBM4
1287-5;Methylmalonyl-CoA
from: 1287-5
O=C(C(C)C[C@@H](C(O)=O)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
71287-7cxmBM5
1287-6;Methylmalonyl-CoA
from: 1287-6
O=C(C(C)C[C@@H]([C@H](O)[C@H](C(O)=O)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Inactive': ['DH']}
81287-8cxmBM6
1287-7;Methylmalonyl-CoA
from: 1287-7
O=C(C(C)C[C@@H]([C@H](O)[C@H]([C@@H](O)[C@@H](C(O)=O)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Inactive': ['DH']}
91287-9cxmCM7
1287-8;Methylmalonyl-CoA
from: 1287-8
O=C(C(C)C[C@@H]([C@H](O)[C@H]([C@@H](O)[C@@H]([C@H](O)[C@@H](C(O)=O)C)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Inactive': ['DH']}
101287-10cxmDM8
1287-9;Methylmalonyl-CoA
from: 1287-9
O=C(C(C)C[C@@H]([C@H](O)[C@H]([C@@H](O)[C@@H]([C@H](O)[C@@H]([C@@H](O)[C@H](C(O)=O)C)C)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Inactive': ['DH']}
111287-11cxmEM9
1287-10;Malonyl-CoA
from: 1287-10
O=C(C(C)C[C@@H]([C@H](O)[C@H]([C@@H](O)[C@@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C(O)=O)C)C)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
121287-12cxmEM10
1287-11;Malonyl-CoA
from: 1287-11
O=C(C(C)C[C@@H]([C@H](O)[C@H]([C@@H](O)[C@@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/C(O)=O)C)C)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
131287-13cxmF—
1287-12
from: 1287-12
OC1=C2C3=C(C(C(NC(/C=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C(C)/C2=O)=O)=CC3=O)=O)C(O)C1C—
141287(1)cxm24—
1287-13
from: 1287-13
OC1=C2C3=C(C(C(NC(/C=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C(C)/C2=O)=O)=CC3=O)=O)C([H])C1C—
151287-14?—
1287-13
from: 1287-13
OC(C1=C2C3=O)=C(C)C(O)=C2C(C(NC(/C=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C(C)/C1=O)=O)=C3)=O—
161287(2)cxm24—
1287-14
from: 1287-14
OC(C1=C2C3=O)=C(C)C(O)=C2C(C(NC(/C=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C(C)/C1=O)=O)=C3C)=O—
171287(3)?—
1287(2)
OC(C1=C2C3=O)=C(C)C(O)=C2C(C(NC(/C=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](CO)/C=C(C)/C1=O)=O)=C3C)=O—
181287(4)cxm20, cxm23—
1287(3)
CC(C(O)=C1C(C(NC(/C=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)/C=C/O[C@@](O2)(C)[C@H]3O)=O)=C4C)=O)=C2C3=C1C4=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture