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BGC0001283PKS

Bisenarsan

Producing organism
Streptomyces lividans 1326
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
8
DOI
MIBiG entry
View on MIBiG ↗
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Bisenarsan
C15H28AsO3331.12 Da

Gene Cluster Map25 genes · 32,355 bp

KRKSATDHERKR5 kb32.4 kb visible · 32,355 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)

Pathway Graphsteps arranged in biosynthetic order

8 steps · 7 edges
Step 1
Start
+EPSP
Step 2
Start
+As(V)
Step 7
SLI_RS05050, SLI_RS05055
{'iteration': [([None], ‘P…
Step 3
SLI_RS05090
Step 4
SLI_RS05095
Step 5
SLI_RS05065
Step 6
SLI_RS05045
Step 8
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions8 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11283-1Start—
EPSP
O=C([O-])C1=CC(OP([O-])([O-])=O)[C@@H](O)[C@H](OC(C([O-])=O)=C)C1—
21283-2Start—
As(V)
O=[As](O)(O)O—
31283-3SLI_RS05090—
1283-1;1283-2
from: 1283-1, 1283-2
O=[As](O)(OC(C([O-])=O)=C)O—
41283-4SLI_RS05095—
1283-3
from: 1283-3
O=[As](O)(CC(C(O)=O)=O)O—
51283-5SLI_RS05065—
1283-4
from: 1283-4
O=[As](O)(CC=O)O—
61283-6SLI_RS05045—
1283-5
from: 1283-5
OCC[As](O)(O)=O—
71283-7SLI_RS05050, SLI_RS05055—
CCCC(CC(C)/C=C(C)\C(O)=O)C{'iteration': [([None], ‘Pro…
81283?—
1283-6;1283-7
from: 1283-6, 1283-7
O=[As](O)(CCOC(/C(C)=C\C(CC(C)CCC)C)=O)O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture