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BGC0001237PKS

Thiolactomycin

Producing organism
Salinispora pacifica DSM 45543 = CNS-863
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Salinispora
Biosynthetic class
PKS (Unknown)
Total steps
5
DOI
MIBiG entry
View on MIBiG ↗
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thiolactomycin
C11H14O2S210.07 Da

Gene Cluster Map10 genes · 21,550 bp

ATEKSATDHKRCyKSKSERTE5 kb21.5 kb visible · 21,550 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
CyHeterocyclization (Cy)

Pathway Graphsteps arranged in biosynthetic order

5 steps · 4 edges
Step 1
tlmG
+Malonyl-CoA
Step 2
tlmH
{'iteration': [(('KR', 'DH…
Step 3
tlmI, ?
+Cysteine
Step 4
tlmF
Step 5
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions5 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11237-1tlmG—
Malonyl-CoA
CC(O)=O—
21237-2tlmH—
1237-1
from: 1237-1
C/C=C(/C=C(C(C(C)C(O)=O)=O)\C)C{'iteration': [(('KR', 'DH')…
31237-3tlmI, ?—
1237-2;Cysteine
from: 1237-2
CC(/C(O)=C(C)\C([S-])=O)=C\C(C)=C\C—
41237-4tlmF—
1237-3
from: 1237-3
CC(C1/C(C)=C/C)(O1)/C(O)=C(C)\C([S-])=O—
51237?—
1237-4
from: 1237-4
C/C(C=C)=C\[C@@]1(C)SC(C(C)=C1C)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture