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BGC0001230Hybrid

Salinamide A;Salinamide B;Salinamide C;Salinamide D;Salinamide E;Salinamide F;Desmethylsalinamide C;Desmethylsalinamide E

Producing organism
Streptomyces sp. CNB091
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
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C51H69N7O151019.49 Da

Gene Cluster Map14 genes · 48,212 bp

AmTCATECACACAECAECATEATCA10 kb48.2 kb visible · 48,212 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
AmTAminotransferase I/II
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

21 steps · 21 edges
Step 1
sln14
+Isobutyryl-CoA
Step 12
sln11, sln12
Step 2
sln14
+Methylmalonyl-CoA
Step 13
sln9
+Glycine
Step 3
sln14
+Threonine
Step 4
sln8
+(D-Valine/D-Isole…
Step 5
sln7
+para-hydroxy-L-ph…
Step 6
sln7
+L-phenylalanine
Step 7
sln7
+Threonine
Step 8
sln6
+L-serine
Step 9TE
sln6
Step 10TE
sln6
Step 11
sln4
+1230(1)
Step 14TE
sln9
Step 15TE
sln9
Step 16
sln4
+1230(3)
Step 17
sln10
Step 18
sln10
Step 19
sln10
Step 20
?
+1230(5)
Step 21
?
+1230(5)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11230-1sln14—
Isobutyryl-CoA
CC(C(O)=O)C—
21230-2sln14—
1230-1;Methylmalonyl-CoA
from: 1230-1
CC([C@H]([C@H](C(O)=O)C)O)C—
31230-3sln14—
1230-2;Threonine
from: 1230-2
CC([C@H]([C@H](C(N[C@H](C(O)=O)[C@@H](C)O)=O)C)O)C—
41230-4sln8—
1230-3;(D-Valine/D-Isoleucine)
from: 1230-3
CC([C@H]([C@H](C(N[C@H](C(N[C@@H](C(O)=O)[C@H](C[R])C)=O)[C@@H](C)O)=O)C)O)C—
51230-5sln7—
1230-4;para-hydroxy-L-phenylglycine
from: 1230-4
CC([C@H]([C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(O)=O)C1=CC=C(O)C=C1)=O)[C@H](C[R])C)=O)[C@@H](C)O)=O)C)O)C—
61230-6sln7—
1230-5;L-phenylalanine
from: 1230-5
CC([C@H]([C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N([C@H](C(O)=O)CC1=CC=CC=C1)C)=O)C2=CC=C(O)C=C2)=O)[C@H](C[R])C)=O)[C@@H](C)O)=O)C)O)C—
71230-7sln7—
1230-6;Threonine
from: 1230-6
CC([C@H]([C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N([C@H](C(N[C@@H](C(O)=O)[C@@H](C)O)=O)CC1=CC=CC=C1)C)=O)C2=CC=C(O)C=C2)=O)[C@H](C[R])C)=O)[C@@H](C)O)=O)C)O)C—
81230-8sln6—
1230-7;L-serine
from: 1230-7
CC([C@H]([C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N([C@H](C(N[C@@H](C(N[C@H](C(O)=O)CO)=O)[C@@H](C)O)=O)CC1=CC=CC=C1)C)=O)C2=CC=C(O)C=C2)=O)[C@H](C[R])C)=O)[C@@H](C)O)=O)C)O)C—
91230-9sln6TE
1230-8
from: 1230-8
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](CO)N1)=O)C(N[C@](C(N[C@](C2=CC=C(O)C=C2)([H])C(N([C@@H](CC3=CC=CC=C3)C(N[C@](C1=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)C[R])=O)=O)C—
101230(1)sln6TE
1230-8
from: 1230-8
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](CO)N1)=O)C(N[C@](C(N[C@](C2=CC=C(O)C=C2)([H])C(N([C@@H](CC3=CC=CC=C3)C(N[C@](C1=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)CC)=O)=O)C—
111230(2)sln4—
1230(1)
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](CO)N1)=O)C(N[C@](C(N[C@](C2=CC=C(OC)C=C2)([H])C(N([C@@H](CC3=CC=CC=C3)C(N[C@](C1=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)CC)=O)=O)C—
121230-11sln11, sln12—
CC(/C=C/C(O)=O)=C\C—
131230-12sln9—
1230-11;Glycine
from: 1230-11
O=C(/C=C/C(C)=C/C)NCC(O)=O—
141230-13sln9TE
1230-9;1230-12
from: 1230-9, 1230-12
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](COC(CNC(/C=C/C(C)=C/C)=O)=O)N1)=O)C(N[C@](C(N[C@](C2=CC=C(O)C=C2)([H])C(N([C@@H](CC3=CC=CC=C3)C(N[C@](C1=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)C[R])=O)=O)C—
151230(3)sln9TE
1230-9;1230-12
from: 1230-9, 1230-12
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](COC(CNC(/C=C/C(C)=C/C)=O)=O)N1)=O)C(N[C@](C(N[C@](C2=CC=C(O)C=C2)([H])C(N([C@@H](CC3=CC=CC=C3)C(N[C@](C1=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)CC)=O)=O)C—
161230(4)sln4—
1230(3)
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](COC(CNC(/C=C/C(C)=C/C)=O)=O)N1)=O)C(N[C@](C(N[C@](C2=CC=C(OC)C=C2)([H])C(N([C@@H](CC3=CC=CC=C3)C(N[C@](C1=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)CC)=O)=O)C—
171230-14sln10—
1230-13
from: 1230-13
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](COC(CNC(/C=C/[C@@]1(OC1)[C@@H](C)OC2=CC=C3C=C2)=O)=O)N4)=O)C(N[C@](C(N[C@]3([H])C(N([C@@H](CC5=CC=CC=C5)C(N[C@](C4=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)C[R])=O)=O)C—
181230(5)sln10—
1230-13
from: 1230-13
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](COC(CNC(/C=C/[C@@]1(OC1)[C@@H](C)OC2=CC=C3C=C2)=O)=O)N4)=O)C(N[C@](C(N[C@]3([H])C(N([C@@H](CC5=CC=CC=C5)C(N[C@](C4=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)CC)=O)=O)C—
191230(6)sln10—
1230-13
from: 1230-13
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](COC(CNC(/C=C/[C@@]1(OC1)[C@@H](C)OC2=CC=C3C=C2)=O)=O)N4)=O)C(N[C@](C(N[C@]3([H])C(N([C@@H](CC5=CC=CC=C5)C(N[C@](C4=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])C(C)C[H])=O)=O)C—
201230(7)?—
1230(5)
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](COC(CNC(/C=C/[C@](O)(CCl)[C@@H](C)OC1=CC=C2C=C1)=O)=O)N3)=O)C(N[C@](C(N[C@]2([H])C(N([C@@H](CC4=CC=CC=C4)C(N[C@](C3=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)CC)=O)=O)C—
211230(8)?—
1230(5)
O[C@H](C(C)C)[C@H](C(N[C@@H]([C@@H](C)OC([C@H](COC(CNC(/C=C/[C@](O)(CO)[C@@H](C)OC1=CC=C2C=C1)=O)=O)N3)=O)C(N[C@](C(N[C@]2([H])C(N([C@@H](CC4=CC=CC=C4)C(N[C@](C3=O)([H])[C@@H](C)O)=O)C)=O)=O)([H])[C@@H](C)CC)=O)=O)C—
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