NPdia

BGC0001216Hybrid

Splenocin C

Producing organism: Streptomyces sp. CNQ431
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I);PKS (Unknown)
Total steps: 10
DOI: 10.1021/jacs.5b00728
MIBiG entry: View on MIBiG ↗

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splenocin C

C₂₉H₃₄N₂O₉554.23 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Other

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Enoylreductase (ER)

Ketoreductase (KR)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Acyl carrier (ACP)

Thioesterase (TE)

CoA-ligase (CAL)

10 steps · 8 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1216-1`	Start	—	Tryptophan	`O=C(C(N)CC1=CNC2=C1C=CC=C2)O`	—
2	`1216-2`	(spnF, spnG, spnH, spnI, spnJ, spnK, spnL), (spnO, spnN)	—	1216-1 from: 1216-1	`O=CNC1=C(O)C(C(O)=O)=CC=C1`	—
3	`1216-3`	spnC	M1	1216-2;Threonine from: 1216-2	`O=CNC1=C(O)C(C(N[C@@H](C(O)=O)[C@H](O)C)=O)=CC=C1`	—
4	`1216-4`	spnC	M2	1216-3;Pyruvate from: 1216-3	`O=CNC1=C(O)C(C(N[C@@H](C(O[C@H](C(O)=O)C)=O)[C@H](O)C)=O)=CC=C1`	—
5	`1216-5`	?	—		`O=C([R])/C=C/C1=CC=CC=C1`	—
6	`1216-6`	spnE	—	1216-5 from: 1216-5	`O=C([R])[C@@H](C(O)=O)CC1=CC=CC=C1`	—
7	`1216-7`	spnD	M3	1216-6 from: 1216-6	`O=CNC1=C(O)C(C(N[C@@H](C(O[C@H](C(C(CC2=CC=CC=C2)C(O)=O)=O)C)=O)[C@H](O)C)=O)=CC=C1`	—
8	`1216-8`	spnD	TE	1216-7 from: 1216-7	`O=C1O[C@H](O)[C@@H](C(O[C@@H](C)[C@@H](C1CC2=CC=CC=C2)O)=O)NC(C(C=CC=C3NC=O)=C3O)=O`	—
9	`1216-9`	Start	—		`O=C([R])C(CC)C`	—
10	`1216`	spnB	—	1216-8;1216-9 from: 1216-8, 1216-9	`O=C1O[C@H](O)[C@@H](C(O[C@@H](C)[C@@H](C1CC2=CC=CC=C2)OC(C(CC)C)=O)=O)NC(C(C=CC=C3NC=O)=C3O)=O`	—

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