NPdia

BGC0001215NRPS

Conglobatin

Producing organism: Streptomyces conglobatus
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 8
DOI: 10.1016/j.chembiol.2015.05.010
MIBiG entry: View on MIBiG ↗

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conglobatin

C₂₈H₃₈N₂O₆498.27 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Adenylation (A)

Peptidyl carrier (PCP)

Thioesterase (TE)

Docking N-term

Docking C-term

Aminotransferase I/II

8 steps · 7 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1215-1`	congA	Loading	Glycine	`O=C(NCC(O)=O)[H]`	—
2	`1215-2`	congB	M1a	1215-1 from: 1215-1	`O=C(NCC(O)=O)[H]`	—
3	`1215-3`	congC	M1b	1215-2;Malonyl-CoA from: 1215-2	`O=C(NCC(CC(O)=O)=O)[H]`	—
4	`1215-4`	congC	M2	1215-3;Methylmalonyl-CoA from: 1215-3	`O=C(NCC(C[C@H](O)[C@@H](C)C(O)=O)=O)[H]`	—
5	`1215-5`	congC	M3	1215-4;Methylmalonyl-CoA from: 1215-4	`O=C(NCC(C[C@H](O)[C@@H](C)C[C@@H](C)C(O)=O)=O)[H]`	{'Inactive': ['AT'], 'Domain…
6	`1215-6`	congD	M4	1215-5;Methylmalonyl-CoA from: 1215-5	`O[C@H]([C@@H](C)C[C@@H](C)/C=C(C(O)=O)\C)CC1=CN=CO1`	—
7	`1215-7`	congD	M4	1215-6;1215-6 from: 1215-6, 1215-6	`C[C@@H](C[C@@H](C)/C=C(C(O)=O)\C)[C@@H](OC(/C(C)=C/[C@H](C)C[C@H](C)[C@@H](O)CC1=CN=CO1)=O)CC2=CN=CO2`	—
8	`1215`	congD	TE	1215-7 from: 1215-7	`C[C@@H](C[C@@H](C)/C=C(C(O[C@H]([C@@H](C)C[C@@H](C)/C=C1\C)CC2=CN=CO2)=O)\C)[C@@H](OC1=O)CC3=CN=CO3`	—

Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture