NPdia
← Back to Repository
BGC0001214NRPS

Marformycin A;Marformycin B;Marformycin C:Marformycin D;Marformycin E;Marformycin F

Producing organism
Streptomyces drozdowiczii
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
Loading…
C43H68N8O10856.51 Da

Gene Cluster Map24 genes · 47,529 bp

CACACAECAECCACATEAAmT10 kb47.5 kb visible · 47,529 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
AmTAminotransferase IV
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1M1
AJV88375.1
+L-allo-ilsoleucin…
Step 3
Start
+Tyrosine
Step 2M2
AJV88375.1, AJV88373.1
+Threonine
Step 4
AJV88379.1
Step 5M3
AJV88375.1
Step 6M4
AJV88376.1
+(L-allo-ilsoleuci…
Step 7M5
AJV88383.1;AJV88384.1, …
+L-piperazic acid
Step 8M6
AJV88377.1
+Leucine
Step 9M7
AJV88377.1
+N-Methyl-L-valine
Step 10TE
AJV88377.1
Step 11TE
AJV88377.1
Step 12TE
AJV88377.1
Step 13TE
AJV88377.1
Step 14
AJV88386.1
Step 15
AJV88386.1
Step 16
AJV88386.1
Step 17
AJV88386.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11214-1AJV88375.1M1
L-allo-ilsoleucine/L--Valine
O=C(O)[C@@H](N)[C@H](C)C[R1]—
21214-2AJV88375.1, AJV88373.1M2
1214-1;Threonine
from: 1214-1
O=C(N[C@H](C(O)=O)[C@H](O)C)[C@@H](NC([H])=O)[C@H](C)C[R1]—
31214-3Start—
Tyrosine
OC1=CC=C(CC(N)C(O)=O)C=C1—
41214-4AJV88379.1—
1214-3
from: 1214-3
NC(C(O)=O)CC1=CC=C(OC)C=C1—
51214-5AJV88375.1M3
1214-2;1214-4
from: 1214-2, 1214-4
O=C(N[C@H](C(N[C@H](CC1=CC=C(OC)C=C1)C(O)=O)=O)[C@H](O)C)[C@@H](NC([H])=O)[C@H](C)C[R1]—
61214-6AJV88376.1M4
1214-5;(L-allo-ilsoleucine/L-valine)
from: 1214-5
O=C(N[C@H](C(N[C@H](CC1=CC=C(OC)C=C1)C(N[C@H]([C@H](C[R2])C)C(O)=O)=O)=O)[C@H](O)C)[C@@H](NC([H])=O)[C@H](C)C[R1]—
71214-7AJV88383.1;AJV88384.1, AJV88377.1M5
1214-6;L-piperazic acid
from: 1214-6
O=C(N[C@H](C(N[C@H](CC1=CC=C(OC)C=C1)C(N[C@H]([C@H](C[R2])C)C(N2NCCC[C@H]2C(O)=O)=O)=O)=O)[C@H](O)C)[C@@H](NC([H])=O)[C@H](C)C[R1]—
81214-8AJV88377.1M6
1214-7;Leucine
from: 1214-7
O=C(N[C@H](C(N[C@H](CC1=CC=C(OC)C=C1)C(N[C@H]([C@H](C[R2])C)C(N2NCCC[C@H]2C(O[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)[C@H](O)C)[C@@H](NC([H])=O)[C@H](C)C[R1]—
91214-9AJV88377.1M7
1214-8;N-Methyl-L-valine
from: 1214-8
O=C(N[C@H](C(N[C@H](CC1=CC=C(OC)C=C1)C(N[C@H]([C@H](C[R2])C)C(N2NCCC[C@H]2C(O[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)[C@H](O)C)[C@@H](NC([H])=O)[C@H](C)C[R1]—
101214-10AJV88377.1TE
1214-9
from: 1214-9
O=C(N[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(OC(C)[C@@H]1NC([C@@H](NC([H])=O)[C@H](C)C[R1])=O)=O)=O)[C@@H]2CCCNN2C([C@@H](C(C[R2])C)NC(C(CC3=CC=C(OC)C=C3)CC1=O)=O)=O—
111214(1)AJV88377.1TE
1214-9
from: 1214-9
O=C(N[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(OC(C)[C@@H]1NC([C@@H](NC([H])=O)C(C)C[H])=O)=O)=O)[C@@H]2CCCNN2C([C@@H](C(CC)C)NC(C(CC3=CC=C(OC)C=C3)CC1=O)=O)=O—
121214(2)AJV88377.1TE
1214-9
from: 1214-9
O=C(N[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(OC(C)[C@@H]1NC([C@@H](NC([H])=O)[C@H](C)CC)=O)=O)=O)[C@@H]2CCCNN2C([C@@H](C(CC)C)NC(C(CC3=CC=C(OC)C=C3)CC1=O)=O)=O—
131214(3)AJV88377.1TE
1214-9
from: 1214-9
O=C(N[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(OC(C)[C@@H]1NC([C@@H](NC([H])=O)C(C)C[H])=O)=O)=O)[C@@H]2CCCNN2C([C@@H](C(C[H])C)NC(C(CC3=CC=C(OC)C=C3)CC1=O)=O)=O—
141214-11AJV88386.1—
1214-10
from: 1214-10
O=C(N[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(OC(C)[C@@H]1NC([C@@H](NC([H])=O)[C@H](C)C[R1])=O)=O)=O)[C@@H]2C[C@H](O)CNN2C([C@@H](C(C[R2])C)NC(C(CC3=CC=C(OC)C=C3)CC1=O)=O)=O—
151214(4)AJV88386.1—
1214-10
from: 1214-10
O=C(N[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(OC(C)[C@@H]1NC([C@@H](NC([H])=O)C(C)C[H])=O)=O)=O)[C@@H]2C[C@H](O)CNN2C([C@@H](C(CC)C)NC(C(CC3=CC=C(OC)C=C3)CC1=O)=O)=O—
161214(5)AJV88386.1—
1214-10
from: 1214-10
O=C(N[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(OC(C)[C@@H]1NC([C@@H](NC([H])=O)[C@H](C)CC)=O)=O)=O)[C@@H]2C[C@H](O)CNN2C([C@@H](C(CC)C)NC(C(CC3=CC=C(OC)C=C3)CC1=O)=O)=O—
171214(6)AJV88386.1—
1214-10
from: 1214-10
O=C(N[C@@H](CC(C)C)C(N(C)[C@@H](C(C)C)C(OC(C)[C@@H]1NC([C@@H](NC([H])=O)C(C)C[H])=O)=O)=O)[C@@H]2C[C@H](O)CNN2C([C@@H](C(C[H])C)NC(C(CC3=CC=C(OC)C=C3)CC1=O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture