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BGC0001200PKS

Lorneic acid A

Producing organism
Streptomyces sp. NBRC 109706
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗
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lorneic acid A
C17H22O2258.16 Da

Gene Cluster Map21 genes · 62,017 bp

KSATKSATERKSATERKSATKSATERKSATKSATKSAT10 kb62.0 kb visible · 62,017 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1Load
ctg1_orf253
+Malonyl-CoA
Step 2M1
ctg1_orf253
+Malonyl-CoA
Step 3M2
ctg1_orf254
+Malonyl-CoA
Step 4M3
ctg1_orf254
+Malonyl-CoA
Step 5M4
ctg1_orf255
+Methylmalonyl-CoA
Inactive: ER
Step 6M5
ctg1_orf256
+Malonyl-CoA
Step 7M6
ctg1_orf256
+Malonyl-CoA
Step 8M7
ctg1_orf256
+Malonyl-CoA
Step 9TE
ctg1_orf256
Step 10
ctg1_orf257
Step 11
?
Step 12
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11200-1ctg1_orf253Loading
Malonyl-CoA
O=C(C)O—
21200-2ctg1_orf253M1
1200-1;Malonyl-CoA
from: 1200-1
O=C(CCC)O—
31200-3ctg1_orf254M2
1200-2;Malonyl-CoA
from: 1200-2
O=C(CCCCC)O—
41200-4ctg1_orf254M3
1200-3;Malonyl-CoA
from: 1200-3
O=C(/C=C/CCCCC)O—
51200-5ctg1_orf255M4
1200-4;Methylmalonyl-CoA
from: 1200-4
O=C(/C(C)=C/C=C/CCCCC)O{'Inactive': ['ER']}
61200-6ctg1_orf256M5
1200-5;Malonyl-CoA
from: 1200-5
O=C(/C=C/C(C)=C/C=C/CCCCC)O—
71200-7ctg1_orf256M6
1200-6;Malonyl-CoA
from: 1200-6
O=C(/C=C/C=C/C(C)=C/C=C/CCCCC)O—
81200-8ctg1_orf256M7
1200-7;Malonyl-CoA
from: 1200-7
O=C(/C=C/C=C/C=C/C(C)=C/C=C/CCCCC)O—
91200-9ctg1_orf256TE
1200-8
from: 1200-8
CCCCC/C=C/C=C(C)\C=C/C=C/CCC(O)=O—
101200-10ctg1_orf257—
1200-9
from: 1200-9
CCCCCC1C(O1)/C=C(C)\C=C/C=C/CCC(O)=O—
111200-11?—
1200-10
from: 1200-10
O=C(O)C/C=C/C1=C(C(O)CCCCC)C=C(C)C=C1—
121200?—
1200-11
from: 1200-11
O=C(O)C/C=C/C1=C(/C=C/CCCC)C=C(C)C=C1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture