← Back to Repository
BGC0001199PKS

Akaeolide

Producing organism
Streptomyces sp. NBRC 109706
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
PKS (Unknown)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
Loading…
akaeolide
C22H32O6392.22 Da

Gene Cluster Map25 genes · 63,400 bp

KSKSATKSATERKSKSATKSKSATKSER10 kb63.4 kb visible · 63,400 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1Load
ctg1_orf521
+Malonyl-CoA
Step 2M1
ctg1_orf521
+Methylmalonyl-CoA
Step 3M2
ctg1_orf521
+Methylmalonyl-CoA
Step 4M3
ctg1_orf522
+Malonyl-CoA
Inactive: DH
Step 5M4
ctg1_orf522
+Methylmalonyl-CoA
Step 6M5
ctg1_orf523
+Malonyl-CoA
Step 7M6
ctg1_orf523
+Propylmalonyl-CoA
Inactive: DH
Step 8M7
ctg1_orf524
+Malonyl-CoA
Step 9TE
ctg1_orf524
Step 10
?
Step 11
ctg1_orf525, ctg1_orf528
Step 12
ctg1_orf526
Step 13
ctg1_orf536
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11199-1ctg1_orf521Loading
Malonyl-CoA
O=C(C)O
21199-2ctg1_orf521M1
1199-1;Methylmalonyl-CoA
from: 1199-1
C/C=C(C)/C(O)=O
31199-3ctg1_orf521M2
1199-2;Methylmalonyl-CoA
from: 1199-2
C/C=C(C)/CC(C)C(O)=O
41199-4ctg1_orf522M3
1199-3;Malonyl-CoA
from: 1199-3
C/C=C(C)/CC(C)C(O)CC(O)=O{'Inactive': ['DH']}
51199-5ctg1_orf522M4
1199-4;Methylmalonyl-CoA
from: 1199-4
C/C=C(C)/CC(C)C(O)C/C=C(C)/C(O)=O
61199-6ctg1_orf523M5
1199-5;Malonyl-CoA
from: 1199-5
C/C=C(C)/CC(C)C(O)C/C=C(C)/C(CC(O)=O)=O
71199-7ctg1_orf523M6
1199-6;Propylmalonyl-CoA
from: 1199-6
C/C=C(C)/CC(C)C(O)C/C=C(C)/C(CC(O)C(CCC)C(O)=O)=O{'Inactive': ['DH']}
81199-8ctg1_orf524M7
1199-7;Malonyl-CoA
from: 1199-7
C/C=C(C)/CC(C)C(O)C/C=C(C)/C(CC(O)C(CCC)C(CC(O)=O)=O)=O
91199-9ctg1_orf524TE
1199-8
from: 1199-8
O=C(C(CCC)C(CC(/C(C)=C/CC(C(C)C/C(C)=C/C)O)=O)O1)CC1=O
101199-10?
1199-9
from: 1199-9
O=C(C(CCC)C(CC(/C(C)=C/CC1C(C)CC(CC)(C)O1)=O)O2)CC2=O
111199-11ctg1_orf525, ctg1_orf528
1199-10
from: 1199-10
O=C(C(CCC)C(CC(/C(C)=C/C(O)C1C(C)CC(CC([H])=O)(C)O1)=O)O2)CC2=O
121199-12ctg1_orf526
1199-11
from: 1199-11
O=C(C(CCC)C(C1)OC/2=O)C2=C\CC(O3)(C)CC(C)C3C(O)/C=C(C)/C1=O
131199ctg1_orf536
1199-12
from: 1199-12
O=C(C(CCC)C(CC(/C(C)=C/C(O)C1C(C)CC(CC2)(C)O1)=O)O3)C2C3=O
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture