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BGC0001195Hybrid

Nocardiopsin A;Nocardiopsin B;Nocardiopsin C;Nocardiopsin D

Producing organism
Nocardiopsis sp. CMB-M0232
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Nocardiopsaceae›Nocardiopsis
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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C33H51NO7573.37 Da

Gene Cluster Map19 genes · 76,702 bp

AKSKSKSKSKSKSKSKSKSKSKS20 kb76.7 kb visible · 76,702 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1Load
AJW65407.1
+Methylmalonyl-CoA
Step 12
Start
+L-lysine
Step 2M1
AJW65407.1
+Malonyl-CoA
Step 13
AJW65405.1
Step 3M2
AJW65407.1
+Methylmalonyl-CoA
Step 4M3
AJW65407.1
+Methylmalonyl-CoA
Step 5M4
AJW65408.1
+Malonyl-CoA
Step 6M5
AJW65408.1
+Malonyl-CoA
Step 7M6
AJW65408.1
+Malonyl-CoA
Step 8M7
AJW65409.1
+Methylmalonyl-CoA
Step 9M8
AJW65409.1
+Methylmalonyl-CoA
Step 10M9
AJW65409.1
+Malonyl-CoA
Step 11M10
AJW65410.1
+Malonyl-CoA
Step 14
AJW65406.1
Step 15
AJW65404.1
Step 16
AJW65411.1
Step 17
AJW65406.1
Step 18
AJW65399.1, AJW65400.1,…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11195-1AJW65407.1Loading
Methylmalonyl-CoA
O=C(O)CC—
21195-2AJW65407.1M1
1195-1;Malonyl-CoA
from: 1195-1
OC(CC(O)=O)CC—
31195-3AJW65407.1M2
1195-2;Methylmalonyl-CoA
from: 1195-2
OC(C/C=C(C(O)=O)\C)CC—
41195-4AJW65407.1M3
1195-3;Methylmalonyl-CoA
from: 1195-3
OC(C/C=C(CC(C(O)=O)C)\C)CC—
51195-5AJW65408.1M4
1195-4;Malonyl-CoA
from: 1195-4
OC(C/C=C(CC(C(O)CC(O)=O)C)\C)CC—
61195-6AJW65408.1M5
1195-5;Malonyl-CoA
from: 1195-5
OC(C/C=C(CC(C(O)CC(O)CC(O)=O)C)\C)CC—
71195-7AJW65408.1M6
1195-6;Malonyl-CoA
from: 1195-6
OC(C/C=C(CC(C(O)CC(O)CCCC(O)=O)C)\C)CC—
81195-8AJW65409.1M7
1195-7;Methylmalonyl-CoA
from: 1195-7
OC(C/C=C(CC(C(O)CC(O)CCC/C=C(C(O)=O)\C)C)\C)CC—
91195-9AJW65409.1M8
1195-8;Methylmalonyl-CoA
from: 1195-8
OC(C/C=C(CC(C(O)CC(O)CCC/C=C(C(C(C(O)=O)C)=O)\C)C)\C)CC—
101195-10AJW65409.1M9
1195-9;Malonyl-CoA
from: 1195-9
OC(C/C=C(CC(C(O)CC(O)CCC/C=C(C(C(C(CC(O)=O)=O)C)=O)\C)C)\C)CC—
111195-11AJW65410.1M10
1195-10;Malonyl-CoA
from: 1195-10
OC(C/C=C(CC(C(O)CC(O)CCC/C=C(C(C(C(C/C=C/C(O)=O)=O)C)=O)\C)C)\C)CC—
121195-12Start—
L-lysine
NCCCC[C@@H](C(O)=O)N—
131195-13AJW65405.1—
1195-13
from: 1195-13
O=C(O)[C@H]1NCCCC1—
141195-14AJW65406.1—
1195-11;1195-13
from: 1195-11, 1195-13
OC(C1N(C(/C=C/CCC(C)C(/C(C)=C\CCCC(CC(C(C/C(C)=C/CC(O)CC)C)O)O)=O)=O)CCCC1)=O—
151195-15AJW65404.1—
1195-14
from: 1195-14
OC(C1N(C(/C=C/CCC(C)C(/C(C)=C\CCCC(CC(C(CC2C(O2)CC(O)CC)C)O)O)=O)=O)CCCC1)=O—
161195-16AJW65411.1—
1195-15
from: 1195-15
OC(C1N(C(/C=C/CCC(C)C(/C(C)=C\CCCC(CC(C(CC(C)(O)C(O)CC(O)CC)C)O)O)=O)=O)CCCC1)=O—
171195-17AJW65406.1—
1195-16
from: 1195-16
O=C(/C=C/CCC(C)C(/C(C)=C\CCCC(O)CC(O)C(C)CC(C(O)CC(CC)O)(C)O1)=O)N2CCCCC2C1=O—
181195AJW65399.1, AJW65400.1, ?—
1195-17
from: 1195-17
O=C(/C=C/CCC(C)C(/C(C)=C\CCC1CCC(O1)C(C)CC(C(O)CC(CC)O)(C)O2)=O)N3CCCCC3C2=O—
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