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BGC0001194PKS

Hitachimycin

Producing organism
Embleya scabrispora
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Embleya
Biosynthetic class
PKS (Unknown)
Total steps
17
DOI
MIBiG entry
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hitachimycin
C29H35NO5477.25 Da

Gene Cluster Map22 genes · 72,530 bp

KSKSAAKSKSKSKSKSKSKS10 kb72.5 kb visible · 72,530 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1
Start
+L-Phenylalanine
Step 2
hitA
Step 3
hitB;hitD
Step 4
hitE
Step 5Load
hitC;hitP1
Step 6M1
hitP1
+Malonyl-CoA
Step 7M2
hitP1
+Malonyl-CoA
Step 8M3
hitP2
+Malonyl-CoA
Step 9M4
hitP2
+Malonyl-CoA
Inactive: KR
Step 10M5
hitP5
+Malonyl-CoA
Step 11M6
hitP4
+Malonyl-CoA
Step 12M7
hitP4
+Methylmalonyl-CoA
Step 13M8
hitP4
+Malonyl-CoA
Step 14M9
hitP3
+Malonyl-CoA
Step 15
hitF
Step 16TE
hitP3
Step 17
hitM1, hitM2, hitM3, hi…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11194-1Start—
L-Phenylalanine
N[C@H](C(O)=O)CC1=CC=CC=C1—
21194-2hitA—
1194-1
from: 1194-1
O=C(O)C[C@H](N)C1=CC=CC=C1—
31194-3hitB;hitD—
1194-2
from: 1194-2
O=C(O)C[C@H](N)C1=CC=CC=C1—
41194-4hitE—
1194-3
from: 1194-3
O=C(O)C[C@H](N[R])C1=CC=CC=C1—
51194-5hitC;hitP1Loading
1194-4
from: 1194-4
O=C(O)C[C@H](N[R])C1=CC=CC=C1—
61194-6hitP1M1
1194-5;Malonyl-CoA
from: 1194-5
[R]N[C@@H](C/C=C/C(O)=O)C1=CC=CC=C1—
71194-7hitP1M2
1194-6;Malonyl-CoA
from: 1194-6
[R]N[C@@H](C/C=C/CCC(O)=O)C1=CC=CC=C1—
81194-8hitP2M3
1194-7;Malonyl-CoA
from: 1194-7
[R]N[C@@H](C/C=C/CC[C@H](O)CC(O)=O)C1=CC=CC=C1—
91194-9hitP2M4
1194-8;Malonyl-CoA
from: 1194-8
[R]N[C@@H](C/C=C/CC[C@H](O)CC(CC(O)=O)=O)C1=CC=CC=C1{'Inactive': ['KR']}
101194-10hitP5M5
1194-9;Malonyl-CoA
from: 1194-9
[R]N[C@@H](C/C=C/CC[C@H](O)CC(CC(O)CC(O)=O)=O)C1=CC=CC=C1—
111194-11hitP4M6
1194-10;Malonyl-CoA
from: 1194-10
[R]N[C@@H](C/C=C/CC[C@H](O)CC(CC(O)C/C=C/C(O)=O)=O)C1=CC=CC=C1—
121194-12hitP4M7
1194-11;Methylmalonyl-CoA
from: 1194-11
[R]N[C@@H](C/C=C/CC[C@H](O)CC(CC(O)C/C=C/C=C(C(O)=O)\C)=O)C1=CC=CC=C1—
131194-13hitP4M8
1194-12;Malonyl-CoA
from: 1194-12
[R]N[C@@H](C/C=C/CC[C@H](O)CC(CC(O)C/C=C/C=C(/C=C/C(O)=O)C)=O)C1=CC=CC=C1—
141194-14hitP3M9
1194-13;Malonyl-CoA
from: 1194-13
[R]N[C@@H](C/C=C/CC[C@H](O)CC(CC(O)C/C=C/C=C(/C=C/C=C/C(O)=O)C)=O)C1=CC=CC=C1—
151194-15hitF—
1194-14
from: 1194-14
O=C(O)/C=C/C=C/C(C)=C\C=C\C[C@@H](O)CC(C[C@@H](O)CC/C=C/C[C@H](N)C1=CC=CC=C1)=O—
161194-16hitP3TE
1194-15
from: 1194-15
O=C(N[C@H](C1=CC=CC=C1)C/C=C/CC[C@H](O)C2)/C=C/C=C/C(C)=C\C=C\C[C@@H](O)CC2=O—
171194hitM1, hitM2, hitM3, hitM4, hitM5, hitM6—
1194-16
from: 1194-16
O=C(N[C@H](C1=CC=CC=C1)C/C=C/CC[C@H](O)CC2=O)/C=C/C=C/C(C)=C\[C@@H]3C2=C(O)[C@@H](OC)C3—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture