NPdia
← Back to Repository
BGC0001183PKS

Lobophorin A

Producing organism
Streptomyces sp. FXJ7.023
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
38
DOI
MIBiG entry
View on MIBiG ↗
Loading…
lobophorin A
C61H92N2O191156.63 Da

Gene Cluster Map60 genes · 151,511 bp

20 kb151.5 kb visible · 151,511 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
ECHEnoyl-CoA hydratase
AmTAminotransferase I/II
AmTAminotransferase V
TauDTauD oxygenase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

38 steps · 39 edges
Step 1Load
AGC09484.1
+Malonyl-CoA
Step 15
Start
Step 22
Start
Step 2M1
AGC09484.1
+Methylmalonyl-CoA
Step 16
AGC09490.1;AGC09491.1
Step 23
AGC09478.1
Step 3M2
AGC09484.1
+Malonyl-CoA
Step 17
AGC09492.1
Step 24
AGC09479.1
Step 4M3
AGC09484.1
+Methylmalonyl-CoA
Step 25
AGC09498.1
Step 5M4
AGC09485.1
+Malonyl-CoA
Inactive: DH
Step 26
AGC09481.1
Step 32
AGC09478.1
Step 6M5
AGC09485.1
+Methylmalonyl-CoA
Step 27
AGC09482.1
Step 33
AGC09477.1
Step 7M6
AGC09485.1
+Malonyl-CoA
Step 28
AGC09502.1
Step 34
?
Step 8M7
AGC09485.1
+Malonyl-CoA
Step 29
AGC09501.1
Step 35
?
Step 9M8
AGC09486.1
+Methylmalonyl-CoA
Inactive: DH
Step 30
AGC09496.1
Step 10M9
AGC09499.1
+Methylmalonyl-CoA
Step 31
?
Step 11M10
AGC09499.1
+Methylmalonyl-CoA
Step 12M11
AGC09487.1
+Malonyl-CoA
Inactive: KR
Step 13
?
Step 14
?
Step 18
AGC09489.1
Step 19
AGC09492.1
Step 20
AGC09488.1
Step 21
AGC09488.1
Step 36
AGC09500.1
Step 37
AGC09494.1
Step 38
AGC09495.1, AGC09501.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions38 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11183-1AGC09484.1Loading
Malonyl-CoA
O=C(C)O—
21183-2AGC09484.1M1
1183-1;Methylmalonyl-CoA
from: 1183-1
C/C=C(C)/C(O)=O—
31183-3AGC09484.1M2
1183-2;Malonyl-CoA
from: 1183-2
C/C=C(C)/C=C/C(O)=O—
41183-4AGC09484.1M3
1183-3;Methylmalonyl-CoA
from: 1183-3
C/C=C(C)/C=C/C=C(C)/C(O)=O—
51183-5AGC09485.1M4
1183-4;Malonyl-CoA
from: 1183-4
C/C=C(C)/C=C/C=C(C)/[C@H](O)CC(O)=O{'Inactive': ['DH']}
61183-6AGC09485.1M5
1183-5;Methylmalonyl-CoA
from: 1183-5
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C(O)=O—
71183-7AGC09485.1M6
1183-6;Malonyl-CoA
from: 1183-6
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C(O)=O—
81183-8AGC09485.1M7
1183-7;Malonyl-CoA
from: 1183-7
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/C(O)=O—
91183-9AGC09486.1M8
1183-8;Methylmalonyl-CoA
from: 1183-8
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C(O)=O)C{'Inactive': ['DH']}
101183-10AGC09499.1M9
1183-9;Methylmalonyl-CoA
from: 1183-9
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C[C@@H](C(O)=O)C)C—
111183-11AGC09499.1M10
1183-10;Methylmalonyl-CoA
from: 1183-10
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C[C@@H](/C=C(C(O)=O)\C)C)C—
121183-12AGC09487.1M11
1183-11;Malonyl-CoA
from: 1183-11
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C[C@@H](/C=C(C(CC(O)=O)=O)\C)C)C{'Inactive': ['KR']}
131183-13?—
1183-12
from: 1183-12
O=C(CC(O)=O)/C(C)=C/[C@@H](C)C[C@H](C)[C@H](O)/C=C/C=C/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
141183-14?—
1183-13
from: 1183-13
O=C(CC(O)=O)[C@]1(C)[C@](C=C[C@]2([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]21[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
151183-15Start—
O[C@H](COP(O)(O)=O)C(OP(O)(O)=O)=O—
161183-16AGC09490.1;AGC09491.1—
1183-15
from: 1183-15
O[C@H](CO)C(O)=O—
171183-17AGC09492.1—
1183-16
from: 1183-16
O[C@H](CO)C([R])=O—
181183-18AGC09489.1—
1183-14;1183-17
from: 1183-14, 1183-17
O=C(/C(C(O)=O)=C(O)/C(CO)O)[C@]1(C)[C@](C=C[C@]2([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]21[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
191183-19AGC09492.1—
1183-18
from: 1183-18
O=C(C1=C(O)C(CO)OC1=O)[C@]2(C)[C@](C=C[C@]3([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]32[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
201183-20AGC09488.1—
1183-19
from: 1183-19
O=C(C(C(O1)=O)=C(O)C1=C)[C@]2(C)[C@](C=C[C@]3([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]32[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
211183-21AGC09488.1—
1183-20
from: 1183-20
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/[C@@](C=C5C)([H])[C@@]21C[C@H]5C—
221183-22Start—
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
231183-23AGC09478.1—
1183-22
from: 1183-22
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
241183-24AGC09479.1—
1183-23
from: 1183-23
O[C@H]([C@@H](O)[C@@H]([R])O[C@@H]1C)C1=O—
251183-25AGC09498.1—
1183-24
from: 1183-24
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
261183-26AGC09481.1—
1183-25
from: 1183-25
[R][C@@H](O[C@@H]1C)C[C@@H](N)C1=O—
271183-27AGC09482.1—
1183-26
from: 1183-26
[R][C@@H](O[C@@H]1C)C[C@](C)(N)C1=O—
281183-28AGC09502.1—
1183-27
from: 1183-27
[R][C@@H]1C[C@](C)(N)[C@@H](N)[C@@H](C)O1—
291183-29AGC09501.1—
1183-28
from: 1183-28
[R][C@@H]1C[C@](C)(N)[C@@H](NC)[C@@H](C)O1—
301183-30AGC09496.1—
1183-29
from: 1183-29
[R][C@@H]1C[C@](C)(N)[C@@H](NC(O)=O)[C@@H](C)O1—
311183-31?—
1183-30
from: 1183-30
[R][C@@H]1C[C@](C)(N)[C@@H](NC(OC)=O)[C@@H](C)O1—
321183-32AGC09478.1—
1183-25
from: 1183-25
[R][C@@H](O[C@@H]1C)C[C@@H](O)C1=O—
331183-33AGC09477.1—
1183-32
from: 1183-32
[R][C@@H]1C[C@@H](O)C([C@H](C)O1)=O—
341183-34?—
1183-33
from: 1183-33
[R][C@@H]1C[C@@H](O)[C@@H](O)[C@H](C)O1—
351183-35?—
1183-34
from: 1183-34
[R][C@@H]1C[C@@H](O)[C@@H](OC)[C@H](C)O1—
361183-36AGC09500.1—
1183-21;1183-31
from: 1183-21, 1183-31
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O[C@H]5C[C@](C)(N)[C@@H](NC(OC)=O)[C@@H](C)O5)/C(C)=C/[C@@](C=C6C)([H])[C@@]21C[C@H]6C—
371183-37AGC09494.1—
1183-34;1183-34;1183-36
from: 1183-34, 1183-34, 1183-36
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O[C@H]5C[C@@H](O[C@H]6C[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](C)O5)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O[C@H]7C[C@](C)(N)[C@@H](NC(OC)=O)[C@@H](C)O7)/C(C)=C/[C@@](C=C8C)([H])[C@@]21C[C@H]8C—
381183AGC09495.1, AGC09501.1—
1183-35;1183-37
from: 1183-35, 1183-37
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O[C@H]5C[C@@H](O[C@H]6C[C@@H](O)[C@@H](O[C@@H]7C[C@@H](O)[C@@H](OC)[C@H](C)O7)[C@H](C)O6)[C@@H](O)[C@H](C)O5)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O[C@H]8C[C@](C)(N)[C@@H](NC(OC)=O)[C@@H](C)O8)/C(C)=C/[C@@](C=C9C)([H])[C@@]21C[C@H]9C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture