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BGC0001178NRPS

UK-68,597

Producing organism
Actinoplanes sp. ATCC 53533
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Actinoplanes
Biosynthetic class
NRPS (Type I)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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UK-68,597
C71H63Cl4N7O29S1649.21 Da

Gene Cluster Map46 genes · 80,908 bp

AAAAAAA20 kb80.9 kb visible · 80,908 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
ECHEnoyl-CoA hydratase
AmTAminotransferase I/II
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

11 steps · 4 edges
Step 1M1
AGS77307.1
+4-hydroxyphenylgl…
Step 3M3
AGS77308.1, AGS77318.1
+3,5-dihydroxyphen…
Step 4M4
AGS77309.1
+4-hydroxyphenylgl…
Step 5M5
AGS77309.1
+4-hydroxyphenylgl…
Step 6M6
AGS77309.1, AGS77318.1,…
+β-hydroxytyrosine
Step 7M7
AGS77310.1
+3,5-dihydroxyphen…
Step 8TE
AGS77310.1, ?
Step 9
Start
+Vancosamine
Step 10
Start
+Glucose
Step 2M2
AGS77307.1, AGS77318.1
+Tyrosine
Step 11
?
+?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11178-1AGS77307.1M1
4-hydroxyphenylglycine
OC1=CC=C(C(N)C(O)=O)C=C1—
21178-2AGS77307.1, AGS77318.1M2
1178-1;Tyrosine
from: 1178-1
OC1=CC=C(C(N)C(NC(CC(C=C2)=CC=C2O)C(O)=O)=O)C=C1Cl—
31178-3AGS77308.1, AGS77318.1M3
3,5-dihydroxyphenylglycine
OC1=CC=C(C(N)C(NC(CC(C=C2Cl)=CC=C2O)C(NC(C(O)=O)C3=CC(O)=CC(O)=C3)=O)=O)C=C1Cl—
41178-4AGS77309.1M4
4-hydroxyphenylglycine
OC1=CC=C(C(N)C(NC(CC(C=C2Cl)=CC=C2O)C(NC(C(NC(C(C=C3)=CC=C3O)C(O)=O)=O)C4=CC(O)=CC(O)=C4)=O)=O)C=C1Cl—
51178-5AGS77309.1M5
4-hydroxyphenylglycine
OC1=CC=C(C(N)C(NC(CC(C=C2Cl)=CC=C2O)C(NC(C(NC(C(C=C3)=CC=C3O)C(NC(C(O)=O)C4=CC=C(O)C=C4)=O)=O)C5=CC(O)=CC(O)=C5)=O)=O)C=C1Cl—
61178-6AGS77309.1, AGS77318.1, AGS77322.1M6
β-hydroxytyrosine
OC1=CC=C(C(N)C(NC(CC(C=C2Cl)=CC=C2O)C(NC(C(NC(C(C=C3)=CC=C3O)C(NC(C(CC(C(O)=O)C(O)C4=CC(Cl)=C(O)C=C4)=O)C5=CC(Cl)=C(O)C=C5)=O)=O)C6=CC(O)=CC(O)=C6)=O)=O)C=C1Cl—
71178-7AGS77310.1M7
3,5-dihydroxyphenylglycine
OC1=CC=C(C(N)C(NC(CC(C=C2Cl)=CC=C2O)C(NC(C(NC(C(C=C3)=CC=C3O)C(NC(C(CC(C(NC(C(O)=O)C4=CC(O)=CC(O)=C4)=O)C(O)C5=CC(Cl)=C(O)C=C5)=O)C6=CC(Cl)=C(O)C=C6)=O)=O)C7=CC(O)=CC(O)=C7)=O)=O)C=C1Cl—
81178-8AGS77310.1, ?TE
OC1=C(OC2=C(Cl)C=C3C=C2)C=C([C@H]4NC([C@@H](NC([C@H](NC(C(C5=CC(O6)=C(O)C(Cl)=C5)=O)=O)C3)=O)C7=CC(O)=CC6=C7)=O)C=C1OC8=CC=C([C@H]([C@@H](C(N[C@H](C9=CC(O)=CC(O)=C9C%10=CC([C@H]%11NC4=O)=CC(Cl)=C%10O)C(O)=O)=O)NC%11=O)O)C=C8Cl—
91178-9Start—
Vancosamine
C[C@]1(N)CC(O)O[C@@H](C)[C@H]1O—
101178-10Start—
Glucose
OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O—
111178?—
1178-8;1178-9;1178-10;?
from: 1178-8, 1178-9, 1178-10
ClC1=C(OC2=C(O[C@@H]3[C@H](O[C@H]4O[C@@H](C)[C@@H](O)[C@@](C)(N)C4)[C@@H](O)[C@H](O)[C@@H](CO)O3)C(OC5=CC=C([C@H]([C@@H](C(N[C@H](C6=CC(O)=CC(O)=C6C7=CC([C@H]8NC9=O)=CC(Cl)=C7O)C(O)=O)=O)NC8=O)O)C=C5Cl)=CC([C@H]9NC([C@@H](NC([C@H](NC(C(C%10=CC(O%11)=C(O)C(Cl)=C%10)=O)=O)C%12)=O)C%13=CC(OS(O)(=O)=O)=CC%11=C%13)=O)=C2)C=CC%12=C1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture