NPdia

BGC0001172Hybrid

Chlorizidine A

Producing organism: Streptomyces sp. CNH287
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I);PKS (Type I)
Total steps: 11
DOI: 10.1021/ja409520v
MIBiG entry: View on MIBiG ↗

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chlorizidine A

C₁₈H₁₀Cl₄N₂O₃441.94 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Ketoreductase (KR)

Acyl carrier (ACP)

Adenylation (A)

Acyl carrier (ACP)

Thioesterase (TE)

Terminal reductase

ACP synthase

11 steps · 11 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1172-1`	Start	—	L-proline	`O=C(O)[C@]1([H])CCCN1`	—
2	`1172-2`	(clz14, clz15, clz5);clz18	—	1172-1 from: 1172-1	`O=C(O)C1=CC(Cl)=C(Cl)N1`	—
3	`1172-3`	clz11;clz10	—	1172-2;Malonyl-CoA from: 1172-2	`ClC(NC(CCC(O)=O)=C1)=C1Cl`	—
4	`1172-4`	clz11	—	1172-3;Malonyl-CoA from: 1172-3	`ClC(NC(CCCCC(O)=O)=C1)=C1Cl`	—
5	`1172-5`	clz3	—	1172-4 from: 1172-4	`ClC(NC(CC/C=C/C(O)=O)=C1)=C1Cl`	—
6	`1172-6`	clz4	—	1172-5 from: 1172-5	`ClC(NC(CCCC(C(O)=O)C(O)=O)=C1)=C1Cl`	—
7	`1172-7`	clz6	M1	1172-2;Malonyl-CoA from: 1172-2	`O=C(CC(O)=O)C1=CC(Cl)=C(Cl)N1`	—
8	`1172-8`	clz6	M2	1172-6;1172-7 from: 1172-6, 1172-7	`ClC(C=C1C(CC(C(CCCC2=CC(Cl)=C(Cl)N2)C(O)=O)=O)=O)=C(N1)Cl`	—
9	`1172-9`	clz7	M3	1172-8;Malonyl-CoA from: 1172-8	`ClC(NC(CCCC(C(CC(C(N1)=CC(Cl)=C1Cl)=O)=O)C(CC(O)=O)=O)=C2)=C2Cl`	—
10	`1172-10`	clz7	MTD	1172-9 from: 1172-9	`ClC1=C(Cl)NC(CCCC2=C(O)C(C(N3C4=CC(Cl)=C3Cl)=O)=C4C=C2O)=C1`	—
11	`1172`	clz9	—	1172-10 from: 1172-10	`OC1=CC2=C(C(N3C2=CC(Cl)=C3Cl)=O)C(O)=C1[C@]4([H])CCC5=CC(Cl)=C(Cl)N54`	—

Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture