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BGC0001169PKS

Piericidin A1

Producing organism: Streptomyces marincola
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Type I)
Total steps: 15
DOI: 10.1021/ol4034176 10.1016/j.chembiol.2011.12.018
MIBiG entry: View on MIBiG ↗

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piericidin A1

C₂₅H₃₇NO₄415.27 Da

Gene Cluster Map12 genes · 49,160 bp

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Thioesterase (TE)

Docking N-term

Docking C-term

Methyltransferase

Polyketide cyclase

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1169-1`	AHE80991.1	Loading	Acetyl-CoA	`O=C(O)C`	—
2	`1169-2`	AHE80991.1	M1	1169-1;Methylmalonyl-CoA from: 1169-1	`C/C=C(C)/C(O)=O`	—
3	`1169-3`	AHE80992.1	M2	1169-2;Methylmalonyl-CoA from: 1169-2	`C/C=C(C)/C(O)C(C)C(O)=O`	—
4	`1169-4`	AHE80992.1	M3	1169-3;Methylmalonyl-CoA from: 1169-3	`C/C=C(C)/C(O)C(C)/C=C(C)/C(O)=O`	—
5	`1169-5`	AHE80993.1	M4	1169-4;Malonyl-CoA from: 1169-4	`C/C=C(C)/C(O)C(C)/C=C(C)/C=C/C(O)=O`	—
6	`1169-6`	AHE80994.1	M5	1169-5;Methylmalonyl-CoA from: 1169-5	`C/C=C(C)/C(O)C(C)/C=C(C)/C=C/CC(C)C(O)=O`	—
7	`1169-7`	AHE80995.1	M6	1169-6;Malonyl-CoA from: 1169-6	`C/C=C(C)/C(O)C(C)/C=C(C)/C=C/CC(C)/C=C/C(O)=O`	—
8	`1169-8`	AHE80996.1	M7	1169-7;Methylmalonyl-CoA from: 1169-7	`C/C=C(C)/C(O)C(C)/C=C(C)/C=C/CC(C)/C=C/C(C(C)C(O)=O)=O`	—
9	`1169-9`	AHE80996.1	M8	1169-8;Malonyl-CoA from: 1169-8	`C/C=C(C)/C(O)C(C)/C=C(C)/C=C/CC(C)/C=C/C(C(C)C(CC(O)=O)=O)=O`	—
10	`1169-10`	AHE80996.1	TE	1169-9 from: 1169-9	`C/C=C(C)/[C@H](O)[C@H](C)/C=C(C)/C=C/CC(C)/C=C/C(C(C)C(CC(O)=O)=O)=O`	—
11	`1169-11`	AHE80999.1	—	1169-10 from: 1169-10	`C/C=C(C)/[C@H](O)[C@H](C)/C=C(C)/C=C/CC(C)/C=C/C(C(C)C(CC(N)=O)=O)=O`	—
12	`1169-12`	AHE80998.1	—	1169-11 from: 1169-11	`OC1=C(C)C(C/C=C(C)/C/C=C/C(C)=C/[C@@H](C)[C@@H](O)/C(C)=C/C)=NC(O)=C1`	—
13	`1169-13`	AHE80997.1	—	1169-12 from: 1169-12	`OC1=C(C)C(C/C=C(C)/C/C=C/C(C)=C/[C@@H](C)[C@@H](O)/C(C)=C/C)=NC(OC)=C1`	—
14	`1169-14`	AHE81000.1	—	1169-13 from: 1169-13	`OC1=C(C)C(C/C=C(C)/C/C=C/C(C)=C/[C@@H](C)[C@@H](O)/C(C)=C/C)=NC(OC)=C1O`	—
15	`1169`	AHE81001.1	—	1169-14 from: 1169-14	`OC1=C(C)C(C/C=C(C)/C/C=C/C(C)=C/[C@@H](C)[C@@H](O)/C(C)=C/C)=NC(OC)=C1OC`	—

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