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BGC0001159Hybrid

Marinopyrrole A;Marinopyrrole E;Marinopyrrole D;Marinopyrrole C;Marinopyrrole B

Producing organism
Streptomyces sp. CNQ-418
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗
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C22H12Cl4N2O4507.96 Da

Gene Cluster Map25 genes · 43,083 bp

AKSATTDKSATKSTE10 kb43.1 kb visible · 43,083 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TDTerminal reductase
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

12 steps · 13 edges
Step 1
Start
Step 2
mpy2
Step 3
mpy3, mpy16, mpy15
Step 4M1
mpy7
+Malonyl-CoA
Step 5M2
mpy7
+Malonyl-CoA
Step 6M3
mpy6
+Malonyl-CoA
Step 7
?
Step 8
?
C-halogenation
Step 9
?
N-halogenation
Step 10
?
Step 11
?
Step 12
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11159-1Start—
O=C(O)C1CCCN1—
21159-2mpy2—
1159-1
from: 1159-1
O=C([R])C1CCCN1—
31159-3mpy3, mpy16, mpy15—
1159-2
from: 1159-2
O=C(O)C1=CC(Cl)=C(Cl)N1—
41159-4mpy7M1
1159-3;Malonyl-CoA
from: 1159-3
O=C(CC(O)=O)C1=CC(Cl)=C(Cl)N1—
51159-5mpy7M2
1159-4;Malonyl-CoA
from: 1159-4
O=C(CC(CC(O)=O)=O)C1=CC(Cl)=C(Cl)N1—
61159-6mpy6M3
1159-5;Malonyl-CoA
from: 1159-5
O=C(CC(CC(O)CC(O)=O)=O)C1=CC(Cl)=C(Cl)N1—
71159-7?—
1159-6
from: 1159-6
OC1=C(C(C2=CC(Cl)=C(Cl)N2)=O)C=CC=C1—
81159-8?—
1159-7
from: 1159-7
OC1=C(C(C2=C([R])C(Cl)=C(Cl)N2)=O)C=CC=C1C-halogenation
91159-9?—
1159-7
from: 1159-7
OC1=C(C(C2=CC(Cl)=C(Cl)N2[R])=O)C=CC=C1N-halogenation
101159-10?—
1159-7;1159-8
from: 1159-7, 1159-8
OC1=C(C(C2=CC(Cl)=C(Cl)N2C3([R])C(Cl)=C(Cl)N/C3=C(O)\C4=C(O)C=CC=C4)=O)C=CC=C1—
111159-11?—
1159-7;1159-9
from: 1159-7, 1159-9
OC1=C(C(C2=CC(Cl)=C(Cl)N2C3([H])C(Cl)=C(Cl)N=C3C(C4=C(O)C=CC=C4)=O)=O)C=CC=C1—
121159?—
1159-10/1159-11
from: 1159-10/1159-11
OC1=C(C(C2=CC(Cl)=C(Cl)N2C3=C(C(C4=C(O)C=CC=C4)=O)NC(Cl)=C3Cl)=O)C=CC=C1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture