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BGC0001147NRPS

Disgocidine;Distamycin;Congocidine

Producing organism
Streptomyces netropsis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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C22H27N9O4481.22 Da

Gene Cluster Map21 genes · 28,600 bp

ACNADAmTCERAC5 kb28.6 kb visible · 28,600 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
EREnoylreductase (ER)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

18 steps · 19 edges
Step 1
Start
Step 3
Start
Step 8
Start
Step 2
dst18
Step 4
dst22;dst19
Step 6
dst22;?
Step 5
dst14, dst16
Step 7
?
Step 15
?
Step 9
dst2/?
Step 16
?
Step 10
dst15
Step 17
?/dst2
Step 11
?/dst16
Step 18
dst15
Step 12
?
Step 13
dst2/?
Step 14
dst15
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11147-1Start—
N=C(N)NCC(O)=O—
21147-2dst18—
1147-1
from: 1147-1
N=C(N)NCC(O)=O—
31147-3Start—
OC(C1=CC(NC(C)=O)=CN1)=O—
41147-4dst22;dst19—
1147-3
from: 1147-3
O=C(O)C1=CC(NC(C)=O)=CN1—
51147-5dst14, dst16—
1147-4
from: 1147-4
O=C(O)C1=CC(NC(C2=CC(N)=CN2)=O)=CN1—
61147-6dst22;?—
1147-3
from: 1147-3
O=C(O)C1=CC(NC(C)=O)=CN1—
71147-7?—
1147-2;1147-5
from: 1147-2, 1147-5
O=C(O)C1=CC(NC(C2=CC(NC(CNC(N)=N)=O)=CN2)=O)=CN1—
81147-8Start—
NC(CCN)=N—
91147-9dst2/?—
1147-7;1147-8
from: 1147-7, 1147-8
O=C(NCCC(N)=N)C1=CC(NC(C2=CC(NC(CNC(N)=N)=O)=CN2)=O)=CN1—
101147(1)dst15—
1147-9
from: 1147-9
O=C(NCCC(N)=N)C1=CC(NC(C2=CC(NC(CNC(N)=N)=O)=CN2)=O)=CN1C—
111147-11?/dst16—
1147-4/1147-6
from: 1147-4/1147-6
O=C(O)C1=CC(NC(C2=CC(N)=CN2)=O)=CN1—
121147-12?—
1147-5/1147-11
from: 1147-5/1147-11
O=C(O)C1=CC(NC(C2=CC(NC([H])=O)=CN2)=O)=CN1—
131147-13dst2/?—
1147-12
from: 1147-12
O=C(NCCC(N)=N)C1=CC(NC(C2=CC(NC([H])=O)=CN2)=O)=CN1—
141147(2)dst15—
1147-13
from: 1147-13
O=C(NCCC(N)=N)C1=CC(NC(C2=CC(NC([H])=O)=CN2C)=O)=CN1C—
151147-14?—
1147-5;1147-6
from: 1147-5, 1147-6
O=C(O)C1=CC(NC(C2=CC(NC(C3=CC(N)=CN3)=O)=CN2)=O)=CN1—
161147-15?—
1147-14
from: 1147-14
O=C(O)C1=CC(NC(C2=CC(NC(C3=CC(NC([H])=O)=CN3)=O)=CN2)=O)=CN1—
171147-16?/dst2—
1147-8;1147-15
from: 1147-8, 1147-15
O=C(NCCC(N)=N)C1=CC(NC(C2=CC(NC(C3=CC(NC([H])=O)=CN3)=O)=CN2)=O)=CN1—
181147(3)dst15—
1147-16
from: 1147-16
O=C(NCCC(N)=N)C1=CC(NC(C2=CC(NC(C3=CC(NC([H])=O)=CN3C)=O)=CN2C)=O)=CN1C—
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