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BGC0001119PKS

Divergolide A;Divergolide B;Divergolide C;Divergolide D

Producing organism
Streptomyces sp. HKI0576
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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C31H39NO8553.27 Da

Gene Cluster Map29 genes · 72,571 bp

ERCALKSKSKSKSKSKSKSKSER10 kb72.6 kb visible · 72,571 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
divK
+AHBA
Inactive: KR
Step 2M1
divK
+Methylmalonyl-CoA
Inactive: DH
Step 3M2
divK
+Malonyl-CoA
Step 4M3
divK
+Malonyl-CoA
Inactive: KR
Step 5M4
divL1
+Ethylmalonyl-CoA
Step 6M5
divL2
+Malonyl-CoA
Step 7M6
divL3
+Isobutylmalonyl-C…
Step 8M7
divM
+Methylmalonyl-CoA
Step 9M8
divM
+Malonyl-CoA
Step 10
divN
Step 11
divO
Step 12
divQ
Step 13
?
Step 14
?
Step 15
?
Step 16
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11119-1divKLoading
AHBA
OC1=CC(C(O)=O)=CC(N)=C1{'Inactive': ['KR']}
21119-2divKM1
1119-1;Methylmalonyl-CoA
from: 1119-1
OC1=CC(C(O)[C@@H](C)C(O)=O)=CC(N)=C1{'Inactive': ['DH']}
31119-3divKM2
1119-2;Malonyl-CoA
from: 1119-2
OC1=CC(C(O)[C@@H](C)C(CC(O)=O)=O)=CC(N)=C1—
41119-4divKM3
1119-3;Malonyl-CoA
from: 1119-3
OC1=CC(C(O)[C@@H](C)C(CC(CC(O)=O)=O)=O)=CC(N)=C1{'Inactive': ['KR']}
51119-5divL1M4
1119-4;Ethylmalonyl-CoA
from: 1119-4
OC1=CC(C(O)[C@@H](C)C(CC(CCC(CC)C(O)=O)=O)=O)=CC(N)=C1—
61119-6divL2M5
1119-5;Malonyl-CoA
from: 1119-5
OC1=CC(C(O)[C@@H](C)C(CC(CCC(CC)/C=C/C(O)=O)=O)=O)=CC(N)=C1—
71119-7divL3M6
1119-6;Isobutylmalonyl-CoA
from: 1119-6
OC1=CC(C(O)[C@@H](C)C(CC(CCC(CC)/C=C/CC(CC(C)C)C(O)=O)=O)=O)=CC(N)=C1—
81119-8divMM7
1119-7;Methylmalonyl-CoA
from: 1119-7
OC1=CC(C(O)[C@@H](C)C(CC(CCC(CC)/C=C/CC(CC(C)C)C(C(C)C(O)=O)=O)=O)=O)=CC(N)=C1—
91119-9divMM8
1119-8;Malonyl-CoA
from: 1119-8
OC1=CC(C(O)[C@@H](C)C(CC(CCC(CC)/C=C/CC(CC(C)C)C(C(C)/C=C/C(O)=O)=O)=O)=O)=CC(N)=C1—
101119-10divN—
1119-9
from: 1119-9
OC1=CC(C(O)[C@@H](C)C(CC(CCC(CC)/C=C/CC(CC(C)C)C(C(C)/C=C/C(C)=O)=O)=O)=O)=CC(NC)=C1—
111119-11divO—
1119-10
from: 1119-10
OC1=CC(C(O)[C@@H](C)C(CC(CCC(CC)/C=C/CC(OC(C(/C=C/C(C)=O)C)=O)CC(C)C)=O)=O)=CC(NC)=C1—
121119-12divQ—
1119-11
from: 1119-11
OC1=CC(C(O)[C@@H](C)C(CC(CCC(CC)/C=C/[C@H](O)C(OC(C(/C=C/C(C)=O)C)=O)CC(C)C)=O)=O)=CC(NC)=C1—
131119(1)?—
1119-12
from: 1119-12
O=C1[C@@H](C)[C@@](O[C@@](C1)(CC[C@@H](CC)/C=C/[C@@H]([C@@H](O)/C=C(C)\C)O2)O3)([H])C4=C3C(NC(C/C=C(C)\C2=O)=O)=CC(O)=C4—
141119(2)?—
1119-12
from: 1119-12
CC(/C(O1)=C/C(CC[C@@H](CC)/C=C/[C@H](O)[C@H](/C=C(C)/C)OC2=O)=O)=CC3=C1C(NC(C/C=C2/C)=O)=CC(O)=C3—
151119(3)?—
1119-12
from: 1119-12
CC1=CC2=C(C(C([C@@](C)(C(O[C@@H](/C=C(C)/C)[C@@H](O)/C=C/[C@H](CC)CCC3=O)=O)C=CC(N4)=O)=C4C2=O)=O)C3=C1O—
161119(4)?—
1119-12
from: 1119-12
CC1=C(O)C2=C(C(C=C(N3)[C@@]4(O)[C@]([H])(/C=C(C(O[C@H]([C@@H](O)/C=C(C)/C)/C=C/[C@H](CC)CCC2=O)=O)/C)C3=O)=O)C4=C1—
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