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BGC0001117NRPS

Himastatin

Producing organism
Streptomyces himastatinicus ATCC 53653
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces violaceusniger group
Biosynthetic class
NRPS (Type I)
Total steps
11
DOI
MIBiG entry
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himastatin
C72H104N14O201484.76 Da

Gene Cluster Map25 genes · 51,421 bp

AAECACAECACECA10 kb51.4 kb visible · 51,421 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
EEpimerization (E)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1M1
hmtI
+Valine
Step 2M2
hmtI;hmtK
+2-keto-isovaleric…
Step 3M3
hmtF
+Glutamine?
Step 4M4
hmtL
+Leucine
Step 5M5
hmtL
+Threonine
Step 6M7
hmtL
+Tryptophan
Step 7TE
hmtL
Step 8
hmtT
Step 9
hmtN
Step 10
?
Step 11
hmtS
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11117-1hmtIM1
Valine
CC(C)[C@H](N)C(O)=O—
21117-2hmtI;hmtKM2
1117-1;2-keto-isovaleric acid
from: 1117-1
CC(C)[C@@H](N)C(O[C@H](C(O)=O)C(C)C)=O—
31117-3hmtFM3
1117-2;Glutamine?
from: 1117-2
CC(C)[C@@H](N)C(O[C@H](C(N1[C@@H](C(O)=O)CCCN1)=O)C(C)C)=O—
41117-4hmtLM4
1117-3;Leucine
from: 1117-3
CC(C)[C@@H](N)C(O[C@H](C(N1[C@@H](C(NC(C(O)=O)CC(C)C)=O)CCCN1)=O)C(C)C)=O—
51117-5hmtLM5
1117-4;Threonine
from: 1117-4
CC(C)[C@@H](N)C(O[C@H](C(N1[C@@H](C(NC(C(N[C@H]([C@@H](O)C)C(O)=O)=O)CC(C)C)=O)CCCN1)=O)C(C)C)=O—
61117-6hmtLM7
1117-5;Tryptophan
from: 1117-5
CC(C)[C@@H](N)C(O[C@H](C(N1[C@@H](C(NC(C(N[C@H]([C@@H](O)C)C(N[C@H](C(O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC(C)C)=O)CCCN1)=O)C(C)C)=O—
71117-7hmtLTE
1117-6
from: 1117-6
O=C([C@](CCCN1)([H])N1C([C@@](C(C)C)([H])OC([C@](C(C)C)([H])NC([C@@](CC2=CNC3=CC=CC=C23)([H])N4)=O)=O)=O)N[C@](CC(C)C)([H])C(N[C@@]([C@](O)([H])C)([H])C4=O)=O—
81117-8hmtT—
1117-7
from: 1117-7
O=C([C@](CCCN1)([H])N1C([C@@](C(C)C)([H])OC([C@](C(C)C)([H])NC([C@@]2([H])N3[C@]4([H])NC5=CC=CC=C5[C@]4(O)C2)=O)=O)=O)N[C@](CC(C)C)([H])C(N[C@@]([C@](O)([H])C)([H])C3=O)=O—
91117-9hmtN—
1117-8
from: 1117-8
O=C([C@](CC(CN1)=O)([H])N1C([C@@](C(C)C)([H])OC([C@](C(C)C)([H])NC([C@@]2([H])N3[C@]4([H])NC5=CC=CC=C5[C@]4(O)C2)=O)=O)=O)N[C@](CC(C)C)([H])C(N[C@@]([C@](O)([H])C)([H])C3=O)=O—
101117-10?—
1117-9
from: 1117-9
O=C([C@](C[C@](O)([H])CN1)([H])N1C([C@@](C(C)C)([H])OC([C@](C(C)C)([H])NC([C@@]2([H])N3[C@]4([H])NC5=CC=CC=C5[C@]4(O)C2)=O)=O)=O)N[C@](CC(C)C)([H])C(N[C@@]([C@](O)([H])C)([H])C3=O)=O—
111117hmtS—
1117-10
from: 1117-10
O=C([C@](C[C@](O)([H])CN1)([H])N1C([C@@](C(C)C)([H])OC([C@](C(C)C)([H])NC([C@@]2([H])N3[C@]4([H])NC5=CC=C(C6=CC=C7C([C@]8(O)C[C@@](N9[C@]8([H])N7)([H])C(N[C@@](C(C)C)([H])C(O[C@](C(C)C)([H])C(N%10[C@@](C[C@](O)([H])CN%10)([H])C(N[C@](CC(C)C)([H])C(N[C@@]([C@](O)([H])C)([H])C9=O)=O)=O)=O)=O)=O)=C6)C=C5[C@]4(O)C2)=O)=O)=O)N[C@](CC(C)C)([H])C(N[C@@]([C@](O)([H])C)([H])C3=O)=O—
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