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BGC0001116Hybrid

Virginiamycin S1

Producing organism
Streptomyces virginiae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
13
DOI
MIBiG entry
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virginiamycin S1
C43H49N7O10823.35 Da

Gene Cluster Map18 genes · 57,999 bp

CCACAEATCyCyAKSKSKSKSKSKSCAKSKS10 kb58.0 kb visible · 57,999 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
CyHeterocyclization (Cy)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
ECHEnoyl-CoA hydratase
MTMethyltransferase
ACPβACP (β-branching)
ACPSACP synthase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1Load
virA
+Isobutyryl-CoA
Step 2M1
virA
Inactive: DH
Step 3M2
virA
Trans-AT
Step 4M3
virA
+Glycine
Step 5M4
virA
Trans-AT
Step 6M5
virA
Trans-AT
Step 7
virC
+Acetyl-CoA
Step 8
virB
Step 9
virD/virE
Step 10M6
virF;virG
Trans-AT
Step 11M7
virG
Trans-AT
Step 12M8
virG;virH
+Serine
Step 13M9;TE
virH;virJ
+proline
Inactive: KS
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11116-1virALoading
Isobutyryl-CoA
O=C(C(C)C)O—
21116-2virAM1
1116-1
from: 1116-1
O[C@H](C(C)C)C(C)C(O)=O{'Inactive': ['DH'], 'transA…
31116-3virAM2
1116-2
from: 1116-2
O[C@H](C(C)C)C(C)/C=C/C(O)=O{'transAT': ['virI', 'Malony…
41116-4virAM3
1116-3;Glycine
from: 1116-3
O=C(/C=C/C([C@H](C(C)C)O)C)NCC(O)=O—
51116-5virAM4
1116-4
from: 1116-4
O=C(/C=C/C([C@H](C(C)C)O)C)NC/C=C/C(O)=O{'transAT': ['virI', 'Malony…
61116-6virAM5
1116-5
from: 1116-5
O=C(/C=C/C([C@H](C(C)C)O)C)NC/C=C/C(CC(O)=O)=O{'transAT': ['virI', 'Malony…
71116-7virC—
1116-6;Acetyl-CoA
from: 1116-6
O=C(/C=C/C([C@H](C(C)C)O)C)NC/C=C/C(C([O-])=O)(O)CC(O)=O—
81116-8virB—
1116-7
from: 1116-7
O=C(/C=C/C([C@H](C(C)C)O)C)NCCCC(CC(O)=O)=C—
91116-9virD/virE—
1116-8
from: 1116-8
O=C(/C=C/C([C@H](C(C)C)O)C)NC/C=C/C(C)=C/C(O)=O—
101116-10virF;virGM6
1116-9
from: 1116-9
O=C(/C=C/C([C@H](C(C)C)O)C)NC/C=C/C(C)=C/[C@@H](O)CC(O)=O{'transAT': ['virI', 'Malony…
111116-11virGM7
1116-10
from: 1116-10
O=C(/C=C/C([C@H](C(C)C)O)C)NC/C=C/C(C)=C/[C@@H](O)CC(CC(O)=O)=O{'transAT': ['virI', 'Malony…
121116-12virG;virHM8
1116-11;Serine
from: 1116-11
O=C(/C=C/C([C@H](C(C)C)O)C)NC/C=C/C(C)=C/[C@@H](O)CC(CC1=NC(O)=CO1)=O—
131116virH;virJM9;TE
1116-12;proline
from: 1116-12
O=C(C1=CCCN12)O[C@H](C(C)C)[C@H](C)/C=C/C(NC/C=C/C(C)=C/[C@@H](O)CC(CC3=NC(C2=O)=CO3)=O)=O{'Inactive': ['KS']}
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture