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BGC0001106Hybrid

Oxazolomycin

Producing organism
Streptomyces albus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
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oxazolomycin
C35H49N3O9655.35 Da

Gene Cluster Map22 genes · 84,836 bp

KSKSKSKSKSKSKSKSKSKSKSKS20 kb84.8 kb visible · 84,836 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
FkFkbH-like
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1
Start
Step 8M1
ozmO
+Formylglycine
Step 2
ozmB
Step 9M2
ozmQ
Trans-AT
Step 3
?
Step 10M3
ozmN
Trans-AT
Step 4
ozmE
Step 11M4
ozmN
Trans-AT
Step 5
ozmG
Step 12M5
ozmN
Trans-AT
Step 6
ozmD
Step 13M6
ozmH
Trans-AT
Step 7
ozmF
Step 14M7
ozmH
+Glycine
Step 15M8
ozmH
Trans-AT
Step 16M9
ozmH
Trans-AT
Step 17M10
ozmH
Trans-AT
Step 18M11
ozmJ
Step 19M12
ozmK
Trans-AT
Step 20M13
ozmL
+Serine
Step 21MC(TE)
ozmL
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11106-1Start—
O[C@@H](C(OP([O-])([O-])=O)=O)COP([O-])([O-])=O—
21106-2ozmB—
1106-1
from: 1106-1
O[C@@H](C(O)=O)COP([O-])([O-])=O—
31106-3?—
1106-2
from: 1106-2
O[C@@H](C(O)=O)CO—
41106-4ozmE—
1106-3
from: 1106-3
O[C@@H](C(O)=O)CO—
51106-5ozmG—
1106-4
from: 1106-4
O[C@@H](C(O)=O)C=O—
61106-6ozmD—
1106-5
from: 1106-5
O[C@@H](C(O)=O)C(C)=O—
71106-7ozmF—
1106-6
from: 1106-6
OC([C@@H](C(C)=O)OC)=O—
81106-8ozmOM1
Formylglycine
O=C(NCC(O)=O)[H]—
91106-9ozmQM2
1106-8
from: 1106-8
O=C(NCC(CC(O)=O)=O)[H]{'transAT': ['ozmM', 'Malony…
101106-10ozmNM3
1106-9
from: 1106-9
OC(/C=C/CC1=CN=CO1)=O{'transAT': ['ozmM', 'Malony…
111106-11ozmNM4
1106-10
from: 1106-10
O=C(O)/C=C\C=C\CC1=CN=CO1{'transAT': ['ozmM', 'Malony…
121106-12ozmNM5
1106-11
from: 1106-11
C/C(C(O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ozmM', 'Malony…
131106-13ozmHM6
1106-12
from: 1106-12
C/C([C@@H](O)C(C)(C)C(O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ozmM', 'Malony…
141106-14ozmHM7
1106-13;Glycine
from: 1106-13
C/C([C@@H](O)C(C)(C)C(NCC(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1—
151106-15ozmHM8
1106-14
from: 1106-14
C/C([C@@H](O)C(C)(C)C(NC/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ozmM', 'Malony…
161106-16ozmHM9
1106-15
from: 1106-15
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ozmM', 'Malony…
171106-17ozmHM10
1106-16
from: 1106-16
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/[C@H](O)[C@@H](C(O)=O)C)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ozmM', 'Malony…
181106-18ozmJM11
1106-7;1106-17
from: 1106-7, 1106-17
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/[C@H](O)[C@@H](C[C@@H](C(O)=O)OC)C)=O)=C/C=C\C=C\CC1=CN=CO1—
191106-19ozmKM12
1106-18
from: 1106-18
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/[C@H](O)[C@@H](C[C@@H](C([C@H](C(O)=O)C)=O)OC)C)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ozmM', 'Malony…
201106-20ozmLM13
1106-19;Serine
from: 1106-19
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/[C@H](O)[C@@H](C[C@@H](C([C@H](C(N(C)[C@H](C(O)=O)CO)=O)C)=O)OC)C)=O)=C/C=C\C=C\CC1=CN=CO1—
211106ozmLMC(TE)
1106-20
from: 1106-20
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/[C@H](O)[C@@H](C[C@@H]([C@]1(O)[C@@H](C)C(N(C)[C@]12C(OC2)=O)=O)OC)C)=O)=C/C=C\C=C\CC3=CN=CO3—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture