NPdia
← Back to Repository
BGC0001101Hybrid

Leinamycin

Producing organism
Streptomyces atroolivaceus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
Loading…
leinamycin
C22H26N2O6S3510.10 Da

Gene Cluster Map71 genes · 135,638 bp

20 kb135.6 kb visible · 135,638 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
CyHeterocyclization (Cy)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
ECHEnoyl-CoA hydratase
MTMethyltransferase
BELBeta-elim. lyase
LPGLPG synthase C
CALCoA-ligase (CAL)
AmTAminotransferase I/II
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1M1
LnmQ;LnmP
+Alanine
Step 10
Start
Step 2M2
LnmI
+Cysteine
Step 3M3
LnmI
Trans-AT
Step 4M4
LnmI;LnmJ
Trans-AT
Step 5M5
LnmJ
Trans-AT
Step 6M6
LnmJ
Trans-AT
Step 7M7
LnmJ
Trans-AT
Step 8M8
LnmJ
Trans-AT
Step 9TE
LnmJ
Step 11
LnmM
Step 12
?
Step 13
LnmA, LnmB, LnmZ
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11101-1LnmQ;LnmPM1
Alanine
C[C@@H](N)C(O)=O—
21101-2LnmIM2
1101-1;Cysteine
from: 1101-1
C[C@@H](N)C1=NC(C(O)=O)=CS1—
31101-3LnmIM3
1101-2
from: 1101-2
C[C@@H](N)C1=NC(/C=C\C(O)=O)=CS1{'transAT': ['LnmG', 'Malony…
41101-4LnmI;LnmJM4
1101-3
from: 1101-3
C[C@@H](N)C1=NC(/C=C\CCC(O)=O)=CS1{'transAT': ['LnmG', 'Malony…
51101-5LnmJM5
1101-4
from: 1101-4
C[C@@H](N)C1=NC(/C=C\CCC(CC(O)=O)=O)=CS1{'transAT': ['LnmG', 'Malony…
61101-6LnmJM6
1101-5
from: 1101-5
C[C@@H](N)C1=NC(/C=C\CCC(C/C=C(C(O)=O)\C)=O)=CS1{'transAT': ['LnmG', 'Malony…
71101-7LnmJM7
1101-6
from: 1101-6
C[C@@H](N)C1=NC(/C=C\CCC(C/C=C(CCC(O)=O)\C)=O)=CS1{'transAT': ['LnmG', 'Malony…
81101-8LnmJM8
1101-7
from: 1101-7
C[C@@H](N)C1=NC(/C=C\CCC(C/C=C(C)/CCC(CC(O)=O)=O)=O)=CS1{'transAT': ['LnmG', 'Malony…
91101-9LnmJTE
1101-8
from: 1101-8
C[C@H]1NC(CC(CC/C(C)=C/CC(/C=C/C=C\C2=CSC1=N2)=O)=O)=O—
101101-10Start—
CC(C(S[R])=O)C([O-])=O—
111101-11LnmM—
1101-9;1101-10
from: 1101-9, 1101-10
C[C@H]1NC(CC(O)(C(C(S[R])=O)C)CC/C(C)=C/CC(/C=C/C=C\C2=CSC1=N2)=O)=O—
121101-12?—
1101-11
from: 1101-11
C[C@H]1NC(CC2(C(C(SS2)=O)C)CC/C(C)=C/CC(/C=C/C=C\C3=CSC1=N3)=O)=O—
131101LnmA, LnmB, LnmZ—
1101-12
from: 1101-12
C[C@H]1NC(CC2([C@@](C)(O)C(SS2=O)=O)CC/C(C)=C/CC(/C=C/C=C\C3=CSC1=N3)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture