NPdia
← Back to Repository
BGC0001100Hybrid

Lankacidin C

Producing organism
Streptomyces rochei
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces rochei group
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
Loading…
lankacidin C
C25H33NO7459.23 Da

Gene Cluster Map15 genes · 30,960 bp

KSKRKSKRKSATKRMTKSCAKS5 kb31.0 kb visible · 30,960 bp total
Biosynthetic (core)
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
TEThioesterase (TE)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1
Start
+1, 3-bisphosphogl…
Step 2
?
Step 3
?
Step 4M1
lkcA
Step 5M2
lkcA;lkcB;lkcC
Trans-AT
Step 6M3
lkcC;lkcF
Trans-AT
Step 7M4
lkcF
Trans-AT
Step 8M5
lkcF;lkcB;lkcC
Trans-AT
Step 9M6
lkcC;lkcF
Trans-AT
Step 10M7
lkcF
Trans-AT
Step 11M8
lkcF;lkcB;lkcC
Trans-AT
Step 12M9
lkcC;lkcG
Trans-AT
Step 13TE
lkcG
Step 14
lkcE
Step 15
?
Step 16
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11100-1Start—
1, 3-bisphosphoglycerate
O=C(C(COP(O)(O)=O)O)OP(O)(O)=O—
21100-2?—
1100-1
from: 1100-1
O[C@@H](C(O)=O)CO—
31100-3?—
1100-2
from: 1100-2
O[C@H](C(O)=O)C—
41100-4lkcAM1
1100-3
from: 1100-3
O=C([C@@H](O)C)NCC(O)=O—
51100-5lkcA;lkcB;lkcCM2
1100-4
from: 1100-4
O=C([C@@H](O)C)NC/C=C(C(O)=O)\C{'transAT': ['lkcD', 'Malony…
61100-6lkcC;lkcFM3
1100-5
from: 1100-5
O=C([C@@H](O)C)NC/C=C(/C=C/C(O)=O)C{'transAT': ['lkcD', 'Malony…
71100-7lkcFM4
1100-6
from: 1100-6
O=C([C@@H](O)C)NC/C=C(/C=C/[C@@H](O)CC(O)=O)C{'transAT': ['lkcD', 'Malony…
81100-8lkcF;lkcB;lkcCM5
1100-7
from: 1100-7
O=C([C@@H](O)C)NC/C=C(/C=C/[C@@H](O)C/C=C(C(O)=O)\C)C{'transAT': ['lkcD', 'Malony…
91100-9lkcC;lkcFM6
1100-8
from: 1100-8
O=C([C@@H](O)C)NC/C=C(/C=C/[C@@H](O)C/C=C(/C=C/C(O)=O)C)C{'transAT': ['lkcD', 'Malony…
101100-10lkcFM7
1100-9
from: 1100-9
O=C([C@@H](O)C)NC/C=C(/C=C/[C@@H](O)C/C=C(/C=C/[C@@H](O)CC(O)=O)C)C{'transAT': ['lkcD', 'Malony…
111100-11lkcF;lkcB;lkcCM8
1100-10
from: 1100-10
O=C([C@@H](O)C)NC/C=C(/C=C/[C@@H](O)C/C=C(/C=C/[C@@H](O)C[C@@H](O)[C@@H](C)C(O)=O)C)C{'transAT': ['lkcD', 'Malony…
121100-12lkcC;lkcGM9
1100-11
from: 1100-11
O=C([C@@H](O)C)NC/C=C(/C=C/[C@@H](O)C/C=C(/C=C/[C@@H](O)C[C@@H](O)[C@@H](C)C([C@H](C)C(O)=O)=O)C)C{'transAT': ['lkcD', 'Malony…
131100-13lkcGTE
1100-12
from: 1100-12
O=C(C(C)=C(O)[C@@H]1C)O[C@]1([H])C[C@H](OC(C)=O)/C=C/C(C)=C/C[C@H](O)/C=C/C(C)=C/CNC([C@H](C)O)=O—
141100-14lkcE—
1100-13
from: 1100-13
O=C([C@]1(C)C([C@@H]2C)=O)O[C@]2([H])C[C@H](OC(C)=O)/C=C/C(C)=C/C[C@H](O)/C=C/C(C)=C/[C@H]1NC([C@H](C)O)=O—
151100-15?—
1100-14
from: 1100-14
O=C([C@]1(C)C([C@@H]2C)=O)O[C@]2([H])C[C@H](OC(C)=O)/C=C/C(C)=C/C[C@H](O)/C=C/C(C)=C/[C@H]1NC(C(C)=O)=O—
161100?—
1100-15
from: 1100-15
O=C([C@]1(C)C([C@@H]2C)=O)O[C@]2([H])C[C@H](O)/C=C/C(C)=C/C[C@H](O)/C=C/C(C)=C/[C@H]1NC(C(C)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture