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BGC0001073Hybrid

Kosinostatin

Producing organism
Micromonospora sp. TP-A0468
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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kosinostatin
C33H32N2O10616.21 Da

Gene Cluster Map61 genes · 82,504 bp

A20 kb82.5 kb visible · 82,504 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
DcDocking C-term
CycPolyketide cyclase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1
AFJ52674.1, AFJ52675.1,…
+Malonyl-CoA, Malonyl-CoA
Step 4
Start
Step 7
Start
Step 10
Start
Step 2
AFJ52659.1, (AFJ52672.1…
Step 5
AFJ52660.1;AFJ52661.1
Step 11
AFJ52669.1/AFJ52670.1
Step 3
?
Step 6
AFJ52664.1, AFJ52664.1,…
Step 12
AFJ52685.1/AFJ52691.1
Step 9
(AFJ52700.1/AFJ52662.1)…
Step 13
AFJ52682.1
Step 14
AFJ52686.1, AFJ52687.1
Step 15
?
Step 16
AFJ52680.1/?
Step 17
AFJ52683.1/AFJ52684.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11073-1AFJ52674.1, AFJ52675.1, AFJ52676.1—
Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
CC(CC(CC(CC(CC(CC(CC(CC(CC(CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O—
21073-2AFJ52659.1, (AFJ52672.1/AFJ52673.1/AFJ52674.1)—
1073-1
from: 1073-1
CC(CC(C1=C(O)C(C2=O)=C(C=C1CC(O)=O)C(C3=C2C(O)=CC=C3)=O)=O)=O—
31073-3?—
1073-2
from: 1073-2
O[C@@]1(C)C[C@H](O)C2=C(O)C(C3=O)=C(C=C2C1C(OC)=O)C(C4=C3C=CC=C4O)=O—
41073-4Start—
OC(C1=CN=CC=C1)=O—
51073-5AFJ52660.1;AFJ52661.1—
1073-4
from: 1073-4
OC(C1=CN=CC=C1)=O—
61073-6AFJ52664.1, AFJ52664.1, AFJ52696.1, AFJ52699.1, AFJ52701.1—
1073-5
from: 1073-5
OC(C1=CC=C(N)C1)=O—
71073-7Start—
[R][C@H]1[C@H](O)[C@H](O)[C@@H](COP([O-])([O-])=O)O1—
91073-8(AFJ52700.1/AFJ52662.1), AFJ52663.1, AFJ52666.1, AFJ52667.1, AFJ52692.1—
1073-6;1073-7
from: 1073-6, 1073-7
OC(C1=CC2=C(NCC2)C1)=O—
101073-9Start—
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)[C@@H]1O—
111073-10AFJ52669.1/AFJ52670.1—
1073-9
from: 1073-9
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)C1=O—
121073-11AFJ52685.1/AFJ52691.1—
1073-10
from: 1073-10
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)C1=O—
131073-12AFJ52682.1—
1073-11
from: 1073-11
O=C1[C@H](C)O[C@H]([R])C[C@H]1O—
141073-13AFJ52686.1, AFJ52687.1—
1073-12
from: 1073-12
C[C@H]1[C@](O)(C(C)=O)[C@H](O)C[C@@H]([R])O1—
151073-14?—
1073-3;1073-8
from: 1073-3, 1073-8
C[C@@]12C[C@H]([C@]3(C=C(CCN4)C4=N3)O2)C5=C(O)C(C6=O)=C(C=C5C1C(OC)=O)C(C7=C6C=CC=C7O)=O—
161073-15AFJ52680.1/?—
1073-14
from: 1073-14
C[C@@]12C[C@H]([C@]3(C=C(CCN4)C4=N3)O2)C5=C(O)C(C6=O)=C(C=C5[C@H]1O)C(C7=C6C=CC=C7O)=O—
171073AFJ52683.1/AFJ52684.1—
1073-13;1073-15
from: 1073-13, 1073-15
C[C@@]12C[C@H]([C@]3(C=C(CCN4)C4=N3)O2)C5=C(O)C(C6=O)=C(C=C5[C@H]1O[C@H]7C[C@@H](O)[C@@](O)(C(C)=O)[C@H](C)O7)C(C8=C6C=CC=C8O)=O—
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