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BGC0001070Hybrid

Kirromycin

Producing organism
Streptomyces collinus Tu 365
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
19
DOI
MIBiG entry
View on MIBiG ↗
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kirromycin
C43H60N2O12796.41 Da

Gene Cluster Map26 genes · 79,889 bp

KSKSKSKSKSAKSKSKSKSKSKSKSKSKSA20 kb79.9 kb visible · 79,889 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1Load
kirAI
+Malonyl-CoA
Trans-AT
Step 2M1
kirAI
Trans-AT
Step 3M2
kirAII
Trans-AT
Step 4M3
kirAII
Trans-AT
Step 5M4
kirAII
Trans-AT
Step 6M5
kirAII
Trans-AT
Step 7M6
kirAIII
+Glycine
Step 8M7
kirAIII;kirAIV
Trans-AT
Step 9M8
kirAIV
Trans-AT
Step 10M9
kirAIV
Trans-AT
Step 11M10
kirAIV
Trans-AT
Step 12M11
kirAIV
Trans-AT
Step 13M12
kirAIV;kirAV
Trans-AT
Step 14M13
kirAV
Trans-AT
Step 15M14
kirAVI
+Methylmalonyl-CoA
Step 16M15
kirAVI
+Malonyl-CoA
Step 17M16
kirB
+β-alanine
Step 18
kirB, ?
Step 19
?, kirM, kirOI, kirOII
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11070-1kirAILoading
Malonyl-CoA
O=C(O)C{'transAT': ['kirCI/kirCII',…
21070-2kirAIM1
1070-1
from: 1070-1
O=C(O)/C=C\C{'Missing': ['DH'], 'transAT…
31070-3kirAIIM2
1070-2
from: 1070-2
C/C=C\C=C\C(O)=O{'transAT': ['kirCI/kirCII',…
41070-4kirAIIM3
1070-3
from: 1070-3
C/C=C\C=C\[C@H](O)C(C)(C)C(O)=O{'transAT': ['kirCI/kirCII',…
51070-5kirAIIM4
1070-4
from: 1070-4
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(O)=O{'transAT': ['kirCI/kirCII',…
61070-6kirAIIM5
1070-5
from: 1070-5
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(O)=O)CC)=O{'transAT': ['kirCI/kirCII',…
71070-7kirAIIIM6
1070-6;Glycine
from: 1070-6
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NCC(O)=O)=O)CC)=O—
81070-8kirAIII;kirAIVM7
1070-7
from: 1070-7
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C(O)=O)=O)CC)=O{'transAT': ['kirCI/kirCII',…
91070-9kirAIVM8
1070-8
from: 1070-8
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C=C(C)/C(O)=O)=O)CC)=O{'transAT': ['kirCI/kirCII',…
101070-10kirAIVM9
1070-9
from: 1070-9
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C=C(C)/C(C(C)C(O)=O)=O)=O)CC)=O{'Missing': ['MT'], 'transAT…
111070-11kirAIVM10
1070-10
from: 1070-10
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C=C(C)/C(C(C)[C@H](O)CC(O)=O)=O)=O)CC)=O{'transAT': ['kirCI/kirCII',…
121070-12kirAIVM11
1070-11
from: 1070-11
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C=C(C)/C(C(C)[C@H](O)C[C@@H](O)CC(O)=O)=O)=O)CC)=O{'transAT': ['kirCI/kirCII',…
131070-13kirAIV;kirAVM12
1070-12
from: 1070-12
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C=C(C)/C(C(C)[C@H](O)C[C@@H](O)C/C=C/C(O)=O)=O)=O)CC)=O{'transAT': ['kirCI/kirCII',…
141070-14kirAVM13
1070-13
from: 1070-13
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C=C(C)/C(C(C)[C@H](O)C[C@@H](O)C/C=C/C=C/C(O)=O)=O)=O)CC)=O{'transAT': ['kirCI/kirCII',…
151070-15kirAVIM14
1070-14;Methylmalonyl-CoA
from: 1070-14
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C=C(C)/C(C(C)[C@H](O)C[C@@H](O)C/C=C/C=C/C=C(C)/C(O)=O)=O)=O)CC)=O—
161070-16kirAVIM15
1070-15;Malonyl-CoA
from: 1070-15
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C=C(C)/C(C(C)[C@H](O)C[C@@H](O)C/C=C/C=C/C=C(C)/C(CC(O)=O)=O)=O)=O)CC)=O—
171070-17kirBM16
1070-16;β-alanine
from: 1070-16
C/C=C\C=C\[C@H](O)C(C)(C)[C@@H](O)CC(C(C(NC/C=C/C=C(C)/C(C(C)[C@H](O)C[C@@H](O)C/C=C/C=C/C=C(C)/C(CC(NCCC(O)=O)=O)=O)=O)=O)CC)=O—
181070-18kirB, ?—
1070-17
from: 1070-17
C/C=C\C=C\[C@H]1C(C)(C)[C@@H](O)[C@@H](O)[C@@](O)([C@@H](C(NC/C=C/C=C(C)/C([C@@H](C)[C@@]2([H])C[C@@H](O)[C@](/C=C/C=C/C=C(C)/C(C3=C(O)C=CNC3=O)=O)([H])O2)=O)=O)CC)O1—
191070?, kirM, kirOI, kirOII—
1070-18
from: 1070-18
C/C=C\C=C\[C@H]1C(C)(C)[C@@H](O)[C@@H](O)[C@@](O)([C@@H](C(NC/C=C/C=C(C)/[C@@H](OC)[C@@H](C)[C@@]2([H])[C@@H](O)[C@@H](O)[C@](/C=C/C=C/C=C(C)/C(C3=C(O)C=CNC3=O)=O)([H])O2)=O)CC)O1—
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