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BGC0001066PKS

Kendomycin

Producing organism
Streptomyces violaceoruber
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces anthocyanicus group
Biosynthetic class
PKS (Type I)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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kendomycin
C29H42O6486.30 Da

Gene Cluster Map20 genes · 66,606 bp

KSKSKSKSKSCALKSKSKS10 kb66.6 kb visible · 66,606 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ECHEnoyl-CoA hydratase
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1
ken2, ken3, ken7
+Malonyl-CoA, Malonyl-CoA
Step 2
ken4
Step 3
ken5
Step 4
ken6
Step 5
ken9
Step 6
ken10
Step 7Load
ken16
Inactive: KR
Step 8M1
ken16
+Methylmalonyl-CoA
Step 9M2
ken16
+Methylmalonyl-CoA
Inactive: DH
Step 10M3
ken16
+Malonyl-CoA
Step 11M4
ken12
+Methylmalonyl-CoA
Step 12M5
ken12
+Methylmalonyl-CoA
Step 13M6
ken13
+Methylmalonyl-CoA
Step 14M7
ken14
+Methylmalonyl-CoA
Step 15M8
ken14
+Malonyl-CoA
Step 16TE
ken14
Step 17
?
Step 18
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11066-1ken2, ken3, ken7—
Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
OC1=CC(CC([R])=O)=CC(O)=C1—
21066-2ken4—
1066-1
from: 1066-1
OC1=CC(C(C([O-])=O)=O)=CC(O)=C1—
31066-3ken5—
1066-2
from: 1066-2
OC1=CC(C([H])=O)=CC(O)=C1—
41066-4ken6—
1066-3
from: 1066-3
OC1=CC(C(O)=O)=CC(O)=C1—
51066-5ken9—
1066-4
from: 1066-4
OC1=CC(C(O)=O)=CC(O)=C1C—
61066-6ken10—
1066-5
from: 1066-5
OC1=C(O)C(C(O)=O)=C(O)C(O)=C1C—
71066-7ken16Loading
1066-6
from: 1066-6
OC(C(O)=C1C(O)=O)=C(C(O)=C1O)C{'Inactive': ['KR']}
81066-8ken16M1
1066-7;Methylmalonyl-CoA
from: 1066-7
OC(C(O)=C1/C=C(C(O)=O)\C)=C(C(O)=C1O)C—
91066-9ken16M2
1066-8;Methylmalonyl-CoA
from: 1066-8
OC(C(O)=C1/C=C([C@@H](O)[C@H](C(O)=O)C)\C)=C(C(O)=C1O)C{'Inactive': ['DH']}
101066-10ken16M3
1066-9;Malonyl-CoA
from: 1066-9
OC(C(O)=C1/C=C([C@@H](O)[C@H]([C@H](O)CC(O)=O)C)\C)=C(C(O)=C1O)C—
111066-11ken12M4
1066-10;Methylmalonyl-CoA
from: 1066-10
OC(C(O)=C1/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](C(O)=O)C)C)\C)=C(C(O)=C1O)C—
121066-12ken12M5
1066-11;Methylmalonyl-CoA
from: 1066-11
OC(C(O)=C1/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](/C=C(C(O)=O)\C)C)C)\C)=C(C(O)=C1O)C—
131066-13ken13M6
1066-12;Methylmalonyl-CoA
from: 1066-12
OC(C(O)=C1/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](/C=C(C[C@H](C(O)=O)C)\C)C)C)\C)=C(C(O)=C1O)C—
141066-14ken14M7
1066-13;Methylmalonyl-CoA
from: 1066-13
OC(C(O)=C1/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](/C=C(C[C@H](C[C@@H](C(O)=O)C)C)\C)C)C)\C)=C(C(O)=C1O)C—
151066-15ken14M8
1066-14;Malonyl-CoA
from: 1066-14
OC(C(O)=C1/C=C([C@@H](O)[C@H]([C@H](O)CC[C@@H](/C=C(C[C@H](C[C@@H](C(CC(O)=O)=O)C)C)\C)C)C)\C)=C(C(O)=C1O)C—
161066-16ken14TE
1066-15
from: 1066-15
C/C(C[C@@H](C)C[C@H](C)C(CC(O)=O)=O)=C\[C@@H](C)CC[C@H]1O[C@@H](C2=C(O)C(C(C)=C(O)C2=O)=O)[C@H](C)[C@@H](O)[C@H]1C—
171066-17?—
1066-16
from: 1066-16
C/C(C[C@@H](C)C[C@H](C)C1=O)=C\[C@@H](C)CC[C@H]2O[C@@H](C3=C(O)C(C(C)=C(O)/C3=C\1)=O)[C@H](C)[C@@H](O)[C@H]2C—
181066?—
1066-17
from: 1066-17
C/C(C[C@@H](C)C[C@H](C)[C@@]1(O)C=C2C3=C(O)C(C(C)=C2O1)=O)=C\[C@@H](C)CC[C@H]4O[C@@H]3[C@H](C)[C@@H](O)[C@H]4C—
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