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BGC0001065PKS

Herboxidiene

Producing organism
Streptomyces chromofuscus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
13
DOI
MIBiG entry
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herboxidiene
C25H42O6438.30 Da

Gene Cluster Map7 genes · 53,036 bp

KSATKSATKSATKSATERKSATKSATKSATKSATERKSAT10 kb53.0 kb visible · 53,036 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DcDocking C-term
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1Load
herB
+Methylmalonyl-CoA
Step 2M1
herB
+Methylmalonyl-CoA
Step 3M2
herB
+Methylmalonyl-CoA
Step 4M3
herB
+Methylmalonyl-CoA
Step 5M4
herC
+Malonyl-CoA
Step 6M5
herC
+Methylmalonyl-CoA
Step 7M6
herC
+Methylmalonyl-CoA
Step 8M7
herC
+Malonyl-CoA
Step 9M8
herD
+Malonyl-CoA
Step 10TE
herD
Step 11
herE
Step 12
herF
Step 13
herG
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11065-1herBLoading
Methylmalonyl-CoA
CCC(O)=O—
21065-2herBM1
1065-1;Methylmalonyl-CoA
from: 1065-1
CC[C@H](O)[C@@H](C(O)=O)C—
31065-3herBM2
1065-2;Methylmalonyl-CoA
from: 1065-2
CC[C@H](O)[C@@H](/C=C(C(O)=O)\C)C—
41065-4herBM3
1065-3;Methylmalonyl-CoA
from: 1065-3
CC[C@H](O)[C@@H](/C=C(C[C@@H](C(O)=O)C)\C)C—
51065-5herCM4
1065-4;Malonyl-CoA
from: 1065-4
CC[C@H](O)[C@@H](/C=C(C[C@@H](/C=C/C(O)=O)C)\C)C—
61065-6herCM5
1065-5;Methylmalonyl-CoA
from: 1065-5
CC[C@H](O)[C@@H](/C=C(C[C@@H](/C=C/C=C(C(O)=O)\C)C)\C)C—
71065-7herCM6
1065-6;Methylmalonyl-CoA
from: 1065-6
CC[C@H](O)[C@@H](/C=C(C[C@@H](/C=C/C=C([C@@H](O)[C@H](C(O)=O)C)\C)C)\C)C—
81065-8herCM7
1065-7;Malonyl-CoA
from: 1065-7
CC[C@H](O)[C@@H](/C=C(C[C@@H](/C=C/C=C([C@@H](O)[C@H](CCC(O)=O)C)\C)C)\C)C—
91065-9herDM8
1065-8;Malonyl-CoA
from: 1065-8
CC[C@H](O)[C@@H](/C=C(C[C@@H](/C=C/C=C([C@@H](O)[C@H](CC/C=C/C(O)=O)C)\C)C)\C)C—
101065-10herDTE
1065-9
from: 1065-9
O=C(O)C[C@H]1CC[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C/C(C)=C/[C@@H]([C@H](CC)O)C)C)O1—
111065-11herE—
1065-10
from: 1065-10
O=C(O)C[C@H]1CC[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C[C@@H]2[C@H](O2)[C@@H]([C@H](CC)O)C)C)O1—
121065-12herF—
1065-11
from: 1065-11
O=C(O)C[C@H]1CC[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C[C@@H]2[C@H](O2)[C@@H]([C@H](CC)OC)C)C)O1—
131065herG—
1065-12
from: 1065-12
O=C(O)C[C@H]1CC[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C[C@@H]2[C@H](O2)[C@@H]([C@H]([C@H](O)C)OC)C)C)O1—
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