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BGC0001063Hybrid

Undecylprodigiosin

Producing organism
Streptomyces coelicolor A3(2)
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces albidoflavus group
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
14
DOI
MIBiG entry
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undecylprodigiosin
C25H35N3O393.28 Da

Gene Cluster Map22 genes · 31,641 bp

KSKSKSAmTACALKSATAmTNADTE5 kb31.6 kb visible · 31,641 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
ACPAcyl carrier protein (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
CALCoA-ligase (CAL)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1
Start
+Proline
Step 9
Start
+Acetyl-CoA
Step 2
SCO5891;SCO5889
Step 10
SCO5886;SCO5887;SCO5888
+Malonyl-CoA, Malonyl-CoA
Step 3
SCO5879
Step 11
SCO5892
+Malonyl-CoA
Step 4
SCO5878
Step 12
?
+Glycine
Step 5
SCO5890
+Malonyl-CoA
Step 13
SCO5893
Step 6
?
+Serine
Step 7
SCO5882
Step 8
SCO5895, SCO5898
Step 14
SCO5896
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11063-1Start—
Proline
O=C([O-])C1NCCC1—
21063-2SCO5891;SCO5889—
1063-1
from: 1063-1
O=C(O)C1NCCC1—
31063-3SCO5879—
1063-2
from: 1063-2
O=C(O)C1=CC=CN1—
41063-4SCO5878—
1063-3
from: 1063-3
O=C(O)C1=CC=CN1—
51063-5SCO5890—
1063-4;Malonyl-CoA
from: 1063-4
O=C(CC(O)=O)C1=CC=CN1—
61063-6?—
1063-5;Serine
from: 1063-5
OC1=C(CO)NC(C2=CC=CN2)=C1—
71063-7SCO5882—
1063-6
from: 1063-6
OC1=C(C=O)NC(C2=CC=CN2)=C1—
81063-8SCO5895, SCO5898—
1063-7
from: 1063-7
O=CC1=C(OC)C=C(N1)C2=CC=CN2—
91063-9Start—
Acetyl-CoA
O=C([R])C—
101063-10SCO5886;SCO5887;SCO5888—
1063-9;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
from: 1063-9
CCCCCCCCCCCC(O)=O—
111063-11SCO5892—
1063-10;Malonyl-CoA
from: 1063-10
CCCCCCCCCCCC(CC(O)=O)=O—
121063-12?—
1063-11;Glycine
from: 1063-11
CCCCCCCCCCCC1=CC(CN1)=O—
131063-13SCO5893—
1063-12
from: 1063-12
CCCCCCCCCCCC1=CC=CN1—
141063SCO5896—
1063-8;1063-13
from: 1063-8, 1063-13
CCCCCCCCCCCC(C=C/1)=NC1=C/C2=C(OC)C=C(N2)C3=CC=CN3—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture