NPdia
← Back to Repository
BGC0001052Hybrid

Tirandamycin

Producing organism
Streptomyces sp. 307-9
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗
Loading…
tirandamycin
C22H27NO7417.18 Da

Gene Cluster Map15 genes · 55,522 bp

KSATKSATKSATKSATKSATKSATKSATKSATCA10 kb55.5 kb visible · 55,522 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1Load
ADC79637.1
+Malonyl-CoA
Step 2M1
ADC79637.1
+Methylmalonyl-CoA
Inactive: KR
Step 3M2
ADC79637.1
+Malonyl-CoA
Step 4M3
ADC79637.1
+Methylmalonyl-CoA
Step 5M4
ADC79638.1
+Methylmalonyl-CoA
Step 6
?
Step 7M5
ADC79638.1
+Methylmalonyl-CoA
Step 8M6
ADC79639.1
+Malonyl-CoA
Step 9M7
ADC79639.1
+Malonyl-CoA
Step 10
ADC79642.1
+Glycine
Step 11
?
Step 12
ADC79643.1
Step 13
ADC79647.1
Step 14
ADC79636.1
Step 15
ADC79647.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11052-1ADC79637.1Loading
Malonyl-CoA
O=C(C)O—
21052-2ADC79637.1M1
1052-1;Methylmalonyl-CoA
from: 1052-1
O=C(C)[C@@H](C(O)=O)C{'Inactive': ['KR']}
31052-3ADC79637.1M2
1052-2;Malonyl-CoA
from: 1052-2
O=C(C)[C@@H]([C@H](O)CC(O)=O)C—
41052-4ADC79637.1M3
1052-3;Methylmalonyl-CoA
from: 1052-3
O=C(C)[C@@H]([C@H](O)C/C=C(C(O)=O)\C)C—
51052-5ADC79638.1M4
1052-4;Methylmalonyl-CoA
from: 1052-4
O=C(C)[C@@H]([C@H](O)C/C=C([C@H](O)[C@H](C)C(O)=O)\C)C—
61052-6?—
1052-5
from: 1052-5
O[C@H]1C[C@H]2OC(C)(O[C@H]([C@@H](C(O)=O)C)[C@H]2C)[C@@H]1C—
71052-7ADC79638.1M5
1052-6;Methylmalonyl-CoA
from: 1052-6
O[C@H]1C[C@H]2OC(C)(O[C@H]([C@@H](/C=C(C(O)=O)\C)C)[C@H]2C)[C@@H]1C—
81052-8ADC79639.1M6
1052-7;Malonyl-CoA
from: 1052-7
O[C@H]1C[C@H]2OC(C)(O[C@H]([C@@H](/C=C(/C=C/C(O)=O)C)C)[C@H]2C)[C@@H]1C—
91052-9ADC79639.1M7
1052-8;Malonyl-CoA
from: 1052-8
O[C@H]1C[C@H]2OC(C)(O[C@H]([C@@H](/C=C(/C=C/C(CC(O)=O)=O)C)C)[C@H]2C)[C@@H]1C—
101052-10ADC79642.1—
1052-9;Glycine
from: 1052-9
O[C@H]1C[C@H]2OC(C)(O[C@H]([C@@H](/C=C(/C=C/C(CC(NCC(O)=O)=O)=O)C)C)[C@H]2C)[C@@H]1C—
111052-11?—
1052-10
from: 1052-10
C[C@@H]([C@@H]1[C@@H](C)[C@@H]2O[C@]([C@@H](C)[C@H](O)C2)(C)O1)/C=C(/C=C/C(O)=C3C(CNC/3=O)=O)C—
121052-12ADC79643.1—
1052-11
from: 1052-11
C[C@@H]([C@@H]1[C@@H](C)[C@@H]2O[C@](C(C)=CC2)(C)O1)/C=C(/C=C/C(O)=C3C(CNC/3=O)=O)C—
131052-13ADC79647.1—
1052-12
from: 1052-12
C[C@@H]([C@@H]1[C@@H](C)[C@@H]2O[C@](C(C)=C[C@@H]2O)(C)O1)/C=C(/C=C/C(O)=C3C(CNC/3=O)=O)C—
141052-14ADC79636.1—
1052-13
from: 1052-13
C[C@@H]([C@@H]1[C@@H](C)[C@@H]2O[C@](C(C)=CC2=O)(C)O1)/C=C(/C=C/C(O)=C3C(CNC/3=O)=O)C—
151052ADC79647.1—
1052-14
from: 1052-14
C[C@@H]([C@@H]1[C@@H](C)[C@@H]2O[C@]([C@]([C@@H]3C2=O)(O3)C)(C)O1)/C=C(/C=C/C(O)=C4C(CNC/4=O)=O)C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture