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BGC0001048Hybrid

Tallysomycin A;Tallysomycin B

Producing organism
Streptoalloteichus hindustanus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Streptoalloteichus
Biosynthetic class
NRPS (Type I);PKS (Type I);saccharide (hybrid/tailoring)
Total steps
29
DOI
MIBiG entry
View on MIBiG ↗
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C68H110N22O27S21730.74 Da

Gene Cluster Map40 genes · 80,158 bp

AAAKSACALAAAA20 kb80.2 kb visible · 80,158 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CyHeterocyclization (Cy)
CycPolyketide cyclase
CALCoA-ligase (CAL)
AmTAminotransferase V
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

29 steps · 31 edges
Step 1M5
tlmVI
Step 17
Start
+D-mannose-1-phosp…
Step 22
Start
+D-glucose-1-phosp…
Step 2M4
tlmVI
+Serine
Step 18
tlmC
Step 23
?
Step 3M3
tlmVI;tlmV
+Asparagine
Step 19
tlmD
Step 20
tlmG
Step 24
?
Step 4M9
tlmX
+Asparagine
Step 25
?
Step 5M8
tlmX
+Histidine
Step 26
tlmJ
Step 6
ABL74944.1
Step 7M7
tlmIX
+Alanine
Step 8
tlmVIII
+Malonyl-CoA
Step 9M6
tlmVIII
+Threonine
Step 10
ABL74954.1
+AdoMet
Step 11M2
tlmIV
+Alanine
Step 12M1
tlmIV
+Cysteine
Step 13Load
tlmIV;tlmIII
+Cysteine
Inactive: A
Step 14
ABL74955.1
Step 15
tlmH
Step 16
tlmII
+Terminal amines
Step 21
tlmE, tlmF
Step 27
Step 28
tlmK
Step 29
tlmK
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions29 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11048-1tlmVIM5
[NH2]—
21048-2tlmVIM4
1048-1;Serine
from: 1048-1
NC(C(N)O)=C—
31048-3tlmVI;tlmVM3
1048-2;Asparagine
from: 1048-2
O=C(O)[C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N—
41048-4tlmXM9
1048-3;Asparagine
from: 1048-3
O=C1N=C([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)NC(C(O)=O)C1—
51048-5tlmXM8
1048-4;Histidine
from: 1048-4
O=C1N=C([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)N[C@H](C(N[C@@](C(O)=O)([H])CC2=CNC=N2)=O)C1—
61048-6ABL74944.1—
1048-5
from: 1048-5
NC1=CC(C(N[C@@](C(O)=O)([H])CC2=CNC=N2)=O)=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=N1—
71048-7tlmIXM7
1048-6;Alanine
from: 1048-6
NC1=CC(C(N[C@@](C(N[C@](C)([H])C(O)=O)=O)([H])CC2=CNC=N2)=O)=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=N1—
81048-8tlmVIII—
1048-7;Malonyl-CoA
from: 1048-7
NC1=CC(C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(O)=O)=O)([H])CC2=CNC=N2)=O)=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=N1—
91048-9tlmVIIIM6
1048-8;Threonine
from: 1048-8
NC1=CC(C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(O)=O)=O)=O)([H])CC2=CNC=N2)=O)=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=N1—
101048-10ABL74954.1—
1048-9;AdoMet
from: 1048-9
NC1=C(C)C(C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(O)=O)=O)=O)([H])CC2=CNC=N2)=O)=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=N1—
111048-11tlmIVM2
1048-10;Alanine
from: 1048-10
NC1=C(C)C(C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(NCCC(O)=O)=O)=O)=O)([H])CC2=CNC=N2)=O)=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=N1—
121048-12tlmIVM1
1048-11;Cysteine
from: 1048-11
NC1=C(C)C(C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(NCCC2=NC(C(O)=O)=CS2)=O)=O)=O)([H])CC3=CNC=N3)=O)=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=N1—
131048-13tlmIV;tlmIIILoading
1048-12;Cysteine
from: 1048-12
NC1=C(C)C(C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(NCCC2=NC(C3=NC(C(O)=O)=CS3)=CS2)=O)=O)=O)([H])CC4=CNC=N4)=O)=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=N1{'Inactive': ['A']}
141048-14ABL74955.1—
1048-13
from: 1048-13
O=C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(NCCC1=NC(C2=NC(C(O)=O)=CS2)=CS1)=O)=O)=O)([H])[C@](O)([H])C3=CNC=N3)C4=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=NC(N)=C4C—
151048-15tlmH—
1048-14
from: 1048-14
O=C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(NC(O)C(O)C1=NC(C2=NC(C(O)=O)=CS2)=CS1)=O)=O)=O)([H])[C@](O)([H])C3=CNC=N3)C4=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=NC=C4C—
161048-16tlmII—
1048-15;Terminal amines
from: 1048-15
O=C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(NC(O)C(O)C1=NC(C2=NC(C(N[R])=O)=CS2)=CS1)=O)=O)=O)([H])[C@](O)([H])C3=CNC=N3)C4=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=NC(N)=C4C—
171048-17Start—
D-mannose-1-phosphate
OC[C@H]1O[C@H]([R])[C@@H](O)[C@@H](O)[C@@H]1O—
181048-18tlmC—
1048-17
from: 1048-17
OC[C@H]1O[C@H]([R])[C@@H](O)[C@@H](O)[C@@H]1O—
191048-19tlmD—
1048-18
from: 1048-18
OC[C@H]1O[C@H]([R])[C@@H](O)[C@@H](OC(N)=O)[C@@H]1O—
201048-20tlmG—
1048-18
from: 1048-18
O[C@H]1[C@H](O)[C@H](O)[C@@H]([R])O[C@H]1CO—
211048-21tlmE, tlmF—
1048-16;1048-19;1048-20
from: 1048-16, 1048-19, 1048-20
O=C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(NC(O)C(O)C1=NC(C2=NC(C(N[R])=O)=CS2)=CS1)=O)=O)=O)([H])[C@](O[C@H]3[C@@H](O[C@@H]4[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O4)[C@@H](O)[C@H](O)[C@H](C(O)=O)O3)([H])C5=CNC=N5)C6=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=NC(N)=C6C—
221048-22Start—
D-glucose-1-phosphate
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
231048-23?—
1048-22
from: 1048-22
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
241048-24?—
1048-23
from: 1048-23
O[C@H]([C@@H](O)[C@@H]([R])O[C@@H]1C)C1=O—
251048-25?—
1048-24
from: 1048-24
O[C@@H]([C@@H](O)[C@@H]([R])O[C@H]1C)C1=O—
261048-26tlmJ—
1048-25
from: 1048-25
O[C@@H]([C@@H](O)[C@@H]([R])O1)[C@H](N)[C@@H]1C—
271048-27—
1048-21;1048-26
from: 1048-21, 1048-26
O=C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(N[C@@H](O[C@H]1[C@H](O)[C@H](O)[C@H](N)[C@H](C)O1)C(O)C2=NC(C3=NC(C(N[R])=O)=CS3)=CS2)=O)=O)=O)([H])[C@](O[C@H]4[C@@H](O[C@@H]5[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@H](C(O)=O)O4)([H])C6=CNC=N6)C7=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=NC(N)=C7C—
281048(1)tlmK—
1048-21;1048-26
from: 1048-21, 1048-26
O=C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(NC(O[C@H]1[C@H](O)[C@H](O)[C@H](N)[C@H](C)O1)C(O)C2=NC(C3=NC(C(NCCCC(N)CC(NCCCNCCCCN)=O)=O)=CS3)=CS2)=O)=O)=O)([H])[C@](O[C@H]4[C@@H](O[C@@H]5[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@H](C(O)=O)O4)([H])C6=CNC=N6)C7=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=NC(N)=C7C—
291048(2)tlmK—
1048-21;1048-26
from: 1048-21, 1048-26
O=C(N[C@@](C(N[C@@](C)([H])[C@](O)([H])C([H])([H])C(N[C@]([C@](O)(C)[H])([H])C(NC(O[C@H]1[C@H](O)[C@H](O)[C@H](N)[C@H](C)O1)C(O)C2=NC(C3=NC(C(NCCCNCCCCN)=O)=CS3)=CS2)=O)=O)=O)([H])[C@](O[C@H]4[C@@H](O[C@@H]5[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@H](C(O)=O)O4)([H])C6=CNC=N6)C7=NC([C@@](CC(N)=O)([H])NC[C@](C(N)=O)([H])N)=NC(N)=C7C—
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