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BGC0001046Hybrid

Streptolydigin

Producing organism
Streptomyces lydicus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Type I);saccharide (hybrid/tailoring)
Total steps
24
DOI
MIBiG entry
View on MIBiG ↗
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streptolydigin
C32H44N2O9600.30 Da

Gene Cluster Map38 genes · 80,894 bp

AKSKSKSKSKSKSKSKS20 kb80.9 kb visible · 80,894 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

24 steps · 23 edges
Step 1Load
slgA1
+Malonyl-CoA
Step 9
Start
+Glutamate
Step 16
Start
+Glucose
Step 2M1
slgA1
+Methylmalonyl-CoA
Step 10
slgE1, slgE2
Step 17
slgS1
Step 3M2
slgA1
+Malonyl-CoA
{'Domain_Reuse': ['DH', (s…
Step 11
slgZ
Step 18
slgS2
Step 4M3
slgA1
+Methylmalonyl-CoA
Inactive: DH
Step 19
slgS3
Step 5M4
slgA2
+Methylmalonyl-CoA
Step 20
slgS4
Step 6M5
slgA2
+Methylmalonyl-CoA
Step 21
slgS6
Step 7M6
slgA3
+Malonyl-CoA
Step 22
slgS7
Step 8M7
slgA3
+Malonyl-CoA
Inactive: KR
Step 23
slgS5
Step 12
slgN1;slgN2
Step 13
?
Step 14
(slgO1/slgO2)?
Step 15
slgM
Step 24
slgG
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions24 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11046-1slgA1Loading
Malonyl-CoA
O=C(C)O—
21046-2slgA1M1
1046-1;Methylmalonyl-CoA
from: 1046-1
OC(C)C(C(O)=O)C—
31046-3slgA1M2
1046-2;Malonyl-CoA
from: 1046-2
OC(C)C(/C=C/C(O)=O)C{'Domain_Reuse': ['DH', (sig…
41046-4slgA1M3
1046-3;Methylmalonyl-CoA
from: 1046-3
OC(C)C(/C=C/C(O)C(C(O)=O)C)C{'Inactive': ['DH']}
51046-5slgA2M4
1046-4;Methylmalonyl-CoA
from: 1046-4
OC(C)C(/C=C/C(O)C(C(O)C(C(O)=O)C)C)C—
61046-6slgA2M5
1046-5;Methylmalonyl-CoA
from: 1046-5
OC(C)C(/C=C/C(O)C(C(O)C(/C=C(C(O)=O)\C)C)C)C—
71046-7slgA3M6
1046-6;Malonyl-CoA
from: 1046-6
CC(/C=C(/C=C/C(O)=O)C)C1C(C)C2OC(C)(C(C)C=C2)O1—
81046-8slgA3M7
1046-7;Malonyl-CoA
from: 1046-7
CC(/C=C(/C=C/C(CC(O)=O)=O)C)C1C(C)C2OC(C)(C(C)C=C2)O1{'Inactive': ['KR']}
91046-9Start—
Glutamate
O=C(O)C(N)CCC(O)=O—
101046-10slgE1, slgE2—
1046-9
from: 1046-9
O=C(O)C(N)C(C)C(O)=O—
111046-11slgZ—
1046-10
from: 1046-10
O=C(O)C(N)C(C)C(N)=O—
121046-12slgN1;slgN2—
1046-8;1046-11
from: 1046-8, 1046-11
CC(/C=C(/C=C/C(CC(NC(C(N)C(O)=O)C(O)=O)=O)=O)C)C1C(C)C2OC(C)(C(C)C=C2)O1—
131046-13?—
1046-12
from: 1046-12
CC(/C=C(/C=C/C(C1C(C(C(C(N[R])=O)C)CC1=O)=O)=O)C)C2C(C)C3OC(C)(C(C)C=C3)O2—
141046-14(slgO1/slgO2)?—
1046-13
from: 1046-13
O=C1N[C@H]([C@@H](C)C(N)=O)C(O)=C1C(/C=C/C(C)=C/C([C@@H]2OC3(C)[C@]4(C=C[C@H]([C@H]2C)O3)CO4)C)=O—
151046-15slgM—
1046-14
from: 1046-14
O=C1N[C@H]([C@@H](C)C(NC)=O)C(O)=C1C(/C=C/C(C)=C/C([C@@H]2OC3(C)[C@]4(C=C[C@H]([C@H]2C)O3)CO4)C)=O—
161046-16Start—
Glucose
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CC—
171046-17slgS1—
1046-16
from: 1046-16
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CC—
181046-18slgS2—
1046-17
from: 1046-17
O[C@H]([C@@H](O)[C@@H]([R])O[C@@H]1C)C1=O—
191046-19slgS3—
1046-18
from: 1046-18
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
201046-20slgS4—
1046-19
from: 1046-19
[R][C@@H](O[C@@H]1C)C[C@@H](O)C1=O—
211046-21slgS6—
1046-20
from: 1046-20
[R][C@@H](O[C@@H]1C)CCC1=O—
221046-22slgS7—
1046-21
from: 1046-21
C[C@@H]1CCC([C@H](C)O1)=O—
231046-23slgS5—
1046-22
from: 1046-22
C[C@@H]1CC[C@H](O)[C@H](C)O1—
241046slgG—
1046-15;1046-23
from: 1046-15, 1046-23
O=C1N([C@H]2CC[C@@H](O)[C@@H](C)O2)[C@H]([C@@H](C)C(NC)=O)C(O)=C1C(/C=C/C(C)=C/C([C@@H]3OC4(C)[C@]5(C=C[C@H]([C@H]3C)O4)CO5)C)=O—
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