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BGC0001043Hybrid

SGR PTMs;SGR PTM Compound b;SGR PTM Compound c;SGR PTM Compound d

Producing organism
Streptomyces griseus subsp. griseus NBRC 13350
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗
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C29H38N2O6510.27 Da

Gene Cluster Map6 genes · 16,183 bp

ERKSATDHKRACPCATE2 kb16.2 kb visible · 16,183 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1
Start
+Hexaketide
Step 2
Start
+Hexaketide
Step 3
Start
Step 4
SGR_814
Step 5
SGR_814
Step 6
SGR_812
Step 7
Spontaneous?
Step 8
SGR_813
Step 9
SGR_815
+1043(2)
Step 10
SGR_810/SGR_811
+1043(2)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11043-1Start—
Hexaketide
C/C=C/C=C/C=C/C=C/C=C/C([R])=O—
21043-2Start—
Hexaketide
C/C=C/C=C/C=C/C=C/C(CC([R])=O)=O—
31043-3Start—
[R]C(C(CCCN)C)=O—
41043-4SGR_814—
1043-1;1043-2;1043-3
from: 1043-1, 1043-2, 1043-3
O=C(/C=C/C=C/C=C/C=C/C=C/C)NCCCC(C1=O)NC(C1C(/C=C/C=C/C=C/C=C/C)=O)=O—
51043-5SGR_814—
1043-4
from: 1043-4
O=C(/C=C/C=C/C=C\C=C/C=C/C)NCCCC(C1=O)NC(C1C(/C=C/C=C/C=C/C=C\C)=O)=O—
61043-6SGR_812—
1043-5
from: 1043-5
O=C(/C=C/C=C/C=C/C(CC(CC)C1C)C1/C=C/C=C/C=C/C(C2C3=O)=O)NCCCC3NC2=O—
71043(1)Spontaneous?—
1043-6
from: 1043-6
O=C(/C=C/C=C/[C@]1([H])[C@@](C=C[C@@]2([H])[C@]3([H])[C@@]([C@]21[H])([H])C[C@H](CC)[C@@H]3C)([H])/C=C/C(C4=C5O)=O)NCCCC5NC4=O—
81043(2)SGR_813—
1043-6
from: 1043-6
CC[C@H]([C@@H]1C)C[C@@]2([H])[C@]1([H])[C@@]([C@H](O)/C=C/C=C/C(C3=C(O)C(CCCNC(/C=C/C=C/4)=O)NC3=O)=O)([H])[C@@]4([H])C2—
91043(3)SGR_815—
1043(2)
CC[C@H]([C@@H]1C)C[C@@]2([H])[C@]1([H])[C@@]([C@H](O)/C=C/C=C/C(C3=C(O)C(C(O)CCNC(/C=C/C=C/4)=O)NC3=O)=O)([H])[C@@]4([H])C2—
101043(4)SGR_810/SGR_811—
1043(2)
CC[C@H]([C@@H]1C)C[C@@]2([H])[C@]1([H])[C@@]([C@](O3)([H])[C@@]3([H])[C@@H](O)/C=C/C4=O)([H])[C@@](/C=C/C=C/C(NCCCC5NC(C4=C5O)=O)=O)([H])C2—
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