← Back to Repository
BGC0001041Hybrid

Salinosporamide A

Producing organism
Salinispora tropica CNB-440
Taxonomy
BacteriaActinomycetotaActinomycetesMicromonosporalesMicromonosporaceaeSalinispora
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
20
DOI
MIBiG entry
View on MIBiG ↗
Loading…
salinosporamide A
C15H20ClNO4313.11 Da

Gene Cluster Map31 genes · 42,010 bp

ERKSAKSATATCAAmT10 kb42.0 kb visible · 42,010 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TdTrans-AT docking
AmTAminotransferase IV

Pathway Graphsteps arranged in biosynthetic order

20 steps · 18 edges
Step 1
Start
+SAM
Step 11M0;1
Strop_1024
+Malonyl-CoA, (Ethylmalonyl-CoA…
Step 12
Start
+Shikimic acid
Step 2
Strop_1026
Step 13
?
Step 3
Strop_1035
Step 14
Strop_1040
Step 4
Strop_1028
Step 15
Strop_1039, ?
Step 5
Strop_1026
Step 6
Strop_1026
Step 16
Strop_1023
Step 7
Strop_1017
Step 17
Strop_1021
Step 8
Strop_1031
Step 18M2
Strop_1023
Step 9
Strop_1034
Step 19
?
Step 10
Strop_1018
Step 20
?
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions20 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11041-1Start
SAM
NC1=NC=NC2=C1N=CN2[C@@H]3C[C@H](C[S+](C)CC[C@@H](C([O-])=O)[NH3+])[C@H](O)[C@@H]3O
21041-2Strop_1026
1041-1
from: 1041-1
NC1=NC=NC2=C1N=CN2[C@@H]3C[C@H](CCl)[C@H](O)[C@@H]3O
31041-3Strop_1035
1041-2
from: 1041-2
O[C@H]1[C@@H](CCl)CC([R])[C@H]1O
41041-4Strop_1028
1041-3
from: 1041-3
O[C@H]1[C@@H](CCl)CC(O)[C@H]1O
51041-5Strop_1026
1041-4
from: 1041-4
O[C@H]([C@@H]1O)[C@@H](CCl)CC1=O
61041-6Strop_1026
1041-4
from: 1041-4
O[C@@H](C([O-])=O)[C@@H]([C@@H](CCl)O)O
71041-7Strop_1017
1041-5/1041-6
from: 1041-5/1041-6
O=C(C([O-])=O)C[C@@H](CCl)O
81041-8Strop_1031
1041-7
from: 1041-7
O=C([R])C[C@@H](CCl)O
91041-9Strop_1034
1041-8
from: 1041-8
O=C([R])/C=C/CCl
101041-10Strop_1018
1041-9
from: 1041-9
O=C([R])C(C(O)=O)CCCl
111041-11Strop_1024M0;1
Malonyl-CoA; (Ethylmalonyl-CoA/1041-10)
OC(C(C(O)=O)CC[R])=O
121041-12Start
Shikimic acid
O[C@@H]1C(O)=CC(C(O)=O)C=C1O
131041-13?
1041-12
from: 1041-12
O[C@@H]1CC[C@@](C(O)=O)(C(CC(O)=O)=O)C=C1
141041-14Strop_1040
1041-13
from: 1041-13
O=C(C(O)=O)CC1=CC=CCC1
151041-15Strop_1039, ?
1041-14
from: 1041-14
N[C@H](C(O)=O)CC1=CC=CCC1
161041-16Strop_1023
1041-15
from: 1041-15
[H][C@]1(C[C@H](N)C(O)=O)CCCC=C1
171041-17Strop_1021
1041-16
from: 1041-16
[H][C@]1([C@H](O)[C@H](N)C(O)=O)CCCC=C1
181041-18Strop_1023M2
1041-11;1041-17
from: 1041-11, 1041-17
[H][C@]1([C@H](O)[C@H](NC(C(CC[R])C(C)=O)=O)C(O)=O)CCCC=C1
191041-19?
1041-18
from: 1041-18
O=C1O[C@@]([C@@]1([C@H]([C@H]2CCCC=C2)O)N3)(C)[C@@H](CC[R])C3=O
201041?
1041-19
from: 1041-19
O=C1O[C@@]([C@@]1([C@H]([C@H]2CCCC=C2)O)N3)(C)[C@@H](CCCl)C3=O
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture