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BGC0001039Hybrid

Pyridomycin

Producing organism
Streptomyces pyridomyceticus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
7
DOI
MIBiG entry
View on MIBiG ↗
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pyridomycin
C27H32N4O8540.22 Da

Gene Cluster Map26 genes · 42,448 bp

ACACAKSATCACALTEAmT10 kb42.4 kb visible · 42,448 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
MTMethyltransferase
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

7 steps · 6 edges
Step 1Load
pyrA;pyrU
Step 3
Start
Step 2M1
pyrE
+Lactyl-CoA
Step 4M2
pyrE
Step 5M3
pyrF
+Methylmalonyl-CoA
Step 6M4
pyrG
+2-Methylbutyryl-C…
Step 7TE
pyrG
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions7 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11039-1pyrA;pyrULoading
OC(C1=NC=CC=C1O)=O—
21039-2pyrEM1
1039-1;Lactyl-CoA
from: 1039-1
OC1=CC=CN=C1C(NC(C(O)C)C(O)=O)=O—
31039-3Start—
N[C@H](C(O)=O)CC1=CC=CN=C1—
41039-4pyrEM2
1039-2;1039-3
from: 1039-2, 1039-3
OC1=CC=CN=C1C(NC(C(O)C)C(NC(C(O)=O)CC2=CN=CC=C2)=O)=O—
51039-5pyrFM3
1039-4;Methylmalonyl-CoA
from: 1039-4
OC1=CC=CN=C1C(NC(C(O)C)C(NC(C(C(C(O)=O)C)=O)CC2=CN=CC=C2)=O)=O—
61039-6pyrGM4
1039-5;2-Methylbutyryl-CoA
from: 1039-5
OC1=CC=CN=C1C(NC(C(O)C)C(NC(C(C(C(OC(C(O)=O)C(CC)C)=O)C)=O)CC2=CN=CC=C2)=O)=O—
71039pyrGTE
1039-6
from: 1039-6
O=C(O/C(C(O[C@H](C)[C@@H]1NC(C2=NC=CC=C2O)=O)=O)=C(C)\CC)[C@H](C)[C@H](O)[C@H](CC3=CN=CC=C3)NC1=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture